<P>A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacter...
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https://www.riss.kr/link?id=A107520870
2015
-
학술저널
707-718(12쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacter...
<P>A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior. This review presents current knowledge regarding indole and its derivatives, their biotechnological applications and their role in prokaryotic and eukaryotic systems.</P> <P><B>Trends</B></P> <P>A variety of bacteria, and some plants, produce large quantities of indole, and thus, indole and its derivatives are widespread in prokaryotic and eukaryotic communities. Recently, indole was shown to be an intercellular, interspecies, and interkingdom signaling molecule.</P> <P>Indole and its derivatives can suppress the bacterial pathogenesis of several antibiotic-resistant pathogens by inhibiting quorum sensing and virulence factor production.</P> <P>Insects sense indole, which controls their behavior. Furthermore, indole controls plant defense systems and growth, and modulates oxidative stress, intestinal inflammation, and hormone secretion in animals. Emerging data suggest that indoles may influence human diseases, such as inflammatory, neurological, and metabolic diseases.</P>