Recent Updates on Associations among Various Obesity Metrics and Cognitive Impairment: from Body Mass Index to Sarcopenic Obesity

다국어 초록 (Multilingual Abstract)

Obesity and obesity-associated morbidity continues to be a major public health issue worldwide. Dementia is also a major health concern in aging societies and its prevalence has increased rapidly. Many epidemiologic studies have shown an association between obesity and cognitive impairment, but this relationship is not as well established as other comorbidities. Conflicting results related to the age and sex of participants, and the methodology used to define obesity and dementia may account for the uncertainty in whether obesity is a modifiable risk factor for dementia. More recently, sarcopenia and sarcopenic obesity have been reported to be associated with cognitive impairment. In addition, new mediators such as the muscle-myokine-brain axis and gut-microbiota-brain axis have been suggested and are attracting interest. In this review, we summarize recent evidence on the link between obesity and cognitive impairment, especially dementia. In particular, we focus on various metrics of obesity, from body mass index to sarcopenia and sarcopenic obesity.

참고문헌 (Reference)

1 Park JH, "Western disease is on the rise in Korea" Statistics Research Institute 2012

2 Cereda E, "Weight cycling is associated with body weight excess and abdominal fat accumulation : a cross-sectional study" 30 : 718-723, 2011

3 West RK, "Waist circumference is correlated with poorer cognition in elderly type 2 diabetes women" 12 : 925-929, 2016

4 Janssen I, "Waist circumference and not body mass index explains obesity-related health risk" 79 : 379-384, 2004

5 Turcato E, "Waist circumference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly : their relation with cardiovascular risk factors" 24 : 1005-1010, 2000

6 Chiba I, "Visceral fat accumulation is associated with mild cognitive impairment in community-dwelling older Japanese women" 24 : 352-357, 2020

7 Snijder MB, "Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels : the Hoorn study" 27 : 372-377, 2004

8 McGrath R, "The longitudinal associations of handgrip strength and cognitive function in aging Americans" 21 : 634-639, 2020

9 De Cock AM, "The impact of cognitive impairment on the physical ageing process" 30 : 1297-1306, 2018

10 Stevens J, "The effect of age on the association between body-mass index and mortality" 338 : 1-7, 1998

11 Karlsson IK, "The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences" 11 : 7206-, 2021

12 Taekema DG, "Temporal relationship between handgrip strength and cognitive performance in oldest old people" 41 : 506-512, 2012

13 Beeri MS, "Stability in BMI over time is associated with a better cognitive trajectory in older adults" 18 : 2131-2139, 2022

14 Wu H, "Skeletal muscle inflammation and insulin resistance in obesity" 127 : 43-54, 2017

15 Cesari M, "Skeletal muscle and mortality results from the InCHIANTI Study" 64 : 377-384, 2009

16 Ciudin A, "Sarcopenic obesity: a new challenge in the clinical practice" 67 : 672-681, 2020

17 Hong SH, "Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences" 21 : 494-, 2020

18 Someya Y, "Sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults : the Bunkyo health study" 41 : 1046-1051, 2022

19 Batsis JA, "Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies" 14 : 513-537, 2018

20 Tolea MI, "Sarcopenic obesity and cognitive performance" 13 : 1111-1119, 2018

21 Beeri MS, "Sarcopenia is associated with incident Alzheimer’s dementia, mild cognitive impairment, and cognitive decline" 69 : 1826-1835, 2021

22 Cabett Cipolli G, "Sarcopenia is associated with cognitive impairment in older adults : a systematic review and meta-analysis" 23 : 525-531, 2019

23 Chen LK, "Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia" 15 : 95-101, 2014

24 Abellan van Kan G, "Sarcopenia and cognitive impairment in elderly women : results from the EPIDOS cohort" 42 : 196-202, 2013

25 Peng TC, "Sarcopenia and cognitive impairment : a systematic review and meta-analysis" 39 : 2695-2701, 2020

26 Cruz-Jentoft AJ, "Sarcopenia : European consensus on definition and diagnosis : report of the European Working Group on Sarcopenia in Older People" 39 : 412-423, 2010

27 Matthews KA, "Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States(2015-2060)in adults aged ≥65 years" 15 : 17-24, 2019

28 Perna S, "Osteosarcopenic visceral obesity and osteosarcopenic subcutaneous obesity, two new phenotypes of sarcopenia:prevalence, metabolic profile, and risk factors" 2018 : 6147426-, 2018

29 Singh-Manoux A, "Obesity trajectories and risk of dementia : 28years of follow-up in the Whitehall II Study" 14 : 178-186, 2018

30 Whitmer RA, "Obesity in middle age and future risk of dementia : a 27 year longitudinal population based study" 330 : 1360-, 2005

31 Korean Society for the Study of Obesity, "Obesity fact sheet 2021"

32 Benito-León J, "Obesity and impaired cognitive functioning in the elderly : a population-based cross-sectional study(NEDICES)" 20 : 899-906, 2013

33 남가은 ; 김양현 ; 한경도 ; 정진형 ; 이은정 ; 이원영 ; the Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity, "Obesity Fact Sheet in Korea, 2020: Prevalence of Obesity by Obesity Class from 2009 to 2018" 대한비만학회 30 (30): 141-148, 2021

34 Zamboni M, "Myosteatosis: a relevant, yet poorly explored element of sarcopenia" 10 : 5-6, 2019

35 Bilski J, "Multifactorial mechanism of sarcopenia and sarcopenic obesity:role of physical exercise, microbiota and myokines" 11 : 160-, 2022

36 Gunstad J, "Longitudinal examination of obesity and cognitive function : results from the Baltimore longitudinal study of aging" 34 : 222-229, 2010

37 Tamakoshi K, "Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men" 27 : 1059-1065, 2003

38 Sun Z, "Latelife obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study" 12 : 2005-2017, 2020

39 Lee JS, "Korean dementia observatory 2021" National Medical Center

40 Agustí A, "Interplay between the gut-brain axis, obesity and cognitive function" 12 : 155-, 2018

41 Danat IM, "Impacts of overweight and obesity in older age on the risk of dementia : a systematic literature review and a metaanalysis" 70 : S87-99, 2019

42 Ma Y, "Higher risk of dementia in English older individuals who are overweight or obese" 49 : 1353-1365, 2020

43 West RK, "Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes" 63 : 2446-2451, 2020

44 Chen WL, "Examining the association between quadriceps strength and cognitive performance in the elderly" 94 : e1335-, 2015

45 Anand SS, "Evaluation of adiposity and cognitive function in adults" 5 : e2146324-, 2022

46 Abellan van Kan G, "Epidemiology and consequences of sarcopenia" 13 : 708-712, 2009

47 Donini LM, "Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review" 39 : 2368-2388, 2020

48 Douketis JD, "Canadian guidelines for body weight classification in adults : application in clinical practice to screen for overweight and obesity and to assess disease risk" 172 : 995-998, 2005

49 Roh E, "Body weight variability increases dementia risk among older adults: a nationwide population-based cohort study" 11 : 291-, 2020

50 Ravona-Springer R, "Body weight variability in midlife and risk for dementia in old age" 80 : 1677-1683, 2013

51 Kaze AD, "Body weight variability and risk of cardiovascular outcomes and death in the context of weight loss intervention among patients with type 2 diabetes" 5 : e220055-, 2022

52 Besser LM, "Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease" 28 : 36-43, 2014

53 Rosengren A, "Body mass index, other cardiovascular risk factors, and hospitalization for dementia" 165 : 321-326, 2005

54 Gallucci M, "Body mass index, lifestyles, physical performance and cognitive decline: the “Treviso Longeva (TRELONG)”study" 17 : 378-384, 2013

55 Anstey KJ, "Body mass index in midlife and late-life as a risk factor for dementia : a metaanalysis of prospective studies" 12 : 426-437, 2011

56 Albanese E, "Body mass index in midlife and dementia:systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies" 8 : 165-178, 2017

57 Kim S, "Body mass index and decline of cognitive function" 11 : e0148908-, 2016

58 Arvanitakis Z, "Body mass index and decline in cognitive function in older black and white persons" 73 : 198-203, 2018

59 Power BD, "Body adiposity in later life and the incidence of dementia:the health in men study" 6 : e17902-, 2011

60 West NA, "Body adiposity in late life and risk of dementia or cognitive impairment in a longitudinal community-based study" 64 : 103-109, 2009

61 Qizilbash N, "BMI and risk of dementia in two million people over two decades : a retrospective cohort study" 3 : 431-436, 2015

62 Bahat G, "Associations of sarcopenic obesity versus sarcopenia alone with functionality" 40 : 2851-2859, 2021

63 Bai A, "Associations of sarcopenia and its defining components with cognitive function in community-dwelling oldest old" 21 : 292-, 2021

64 Spauwen PJ, "Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study" 46 : 250-257, 2017

65 Sponholtz TR, "Association of variability in body mass index and metabolic health with cardiometabolic disease risk" 8 : e010793-, 2019

66 Boyle PA, "Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons" 66 : 1339-1344, 2009

67 Shin HY, "Association of grip strength with dementia in a Korean older population" 27 : 500-505, 2012

68 Cho GJ, "Association between waist circumference and dementia in older persons: a nationwide population-based study" 27 : 1883-1891, 2019

69 Hughes TF, "Association between late-life body mass index and dementia : the Kame Project" 72 : 1741-1746, 2009

70 Bays HE, "Adiposopathy is “sick fat” a cardiovascular disease?" 57 : 2461-2473, 2011

71 Gustafson DR, "Adiposity indicators and dementia over 32 years in Sweden" 73 : 1559-1566, 2009

72 Husain MA, "APOE and Alzheimer’s disease : from lipid transport to physiopathology and therapeutics" 15 : 630502-, 2021

73 Jo D, "A new paradigm in sarcopenia : cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction" 147 : 112636-, 2022