Cis-dichlorodiammineplatinum(Ⅱ)가 흰쥐폐의 방사선 손상에 미치는 영향에 관한 실험적 연구 = An Experimetal Study of the Effect of Cis-dichlorodiammineplatinum(Ⅱ) on the Radiation-induced Lung Damage in Rat

다국어 초록 (Multilingual Abstract)

The effects Cis-dichlorodiammineplatinum (Ⅱ) (Cis-DDP) on the irradiated lung were asses-sed by histopathologic changes. In radiation alone group, right lung of rats were exposed toX-ray 10. 15. 20. 30, 40 Gy in a single dose and in combined group. Cis-DDP(6mg/kg) wasadministered immediatelly after irradiation of same dose of X-ray of radiation alone group.Histopathologic examination was done after 4 weeks after experiments. The early histopathologicchanges of lung by irradiation was patchy infiltrations of macrophage in the alveolar space,desquamation of the alveolar septa'e and perivascular inflammatory cell infiltrations whichwas appeared in 10 Gy irradiated group and was more aggravated with incressing radiationdose. The destruction of alveolar septae was noted in 20 Gy irradiation group and it wasseverer in 30 Gy and 40 Gy group. In combined group of radiation and Cis-DDP, the destructionof alveolar septae was. appeared in 15 Gy group and the changes of alveolar space such asedema ana hemorrhage was diffuse and severer than radiation alone group. Degenerative changes of vascular endothelial cells and alveolar epithelial cells with type Ⅱ pneumocytes proliferation were more prominent in combined group than radiation alone group in electron microscopic findings. This result suggests Cis-DDP enhance the radiation pneumonitis of rat lung andenhancement ratio was 1.3 as the endpoint was the destruction of the alveolar septae.