Relationship between Hearing Loss and Dementia Differs According to the Underlying Mechanism

다국어 초록 (Multilingual Abstract)

Background and Purpose The associations between hearing loss (HL) and the mechanisms underlying cognitive impairment (CI) remain unclear. We evaluated the effects of clinical factors, vascular magnetic resonance imaging (MRI) markers, and CI mechanisms on HL.
Methods In total, 112 patients with CI (59% demented) and subjective HL prospectively underwent MRI, amyloid positron-emission tomography (PET), hearing evaluations, and neuropsychological tests including a language comprehension test. Patients were categorized into pure-Alzheimer’s disease-related CI (ADCI), pure-Lewy-body disease-related CI (LBCI), mixed-ADCI/LBCI, and non-ADCI/LBCI groups based on clinical features and PET biomarkers.
Results The risk of peripheral HL [defined as a pure-tone average (PTA) threshold >40 dB] was higher in the pure-LBCI group than in the pure-ADCI and mixed-ADCI/LBCI groups, and lower in the presence of ADCI. The non-ADCI/LBCI group had the most-severe vascular MRI markers and showed a higher risk of peripheral HL than did the pure-ADCI and mixed-ADCI/LBCI groups. While the pure-LBCI group had a higher risk of comprehension dysfunction than the pure-ADCI group regardless of the PTA and the score on the Korean version of the Mini Mental State Examination (K-MMSE), those in the pure-LBCI group even with a better K-MMSE score had a risk of comprehension dysfunction comparable to that in the mixed-ADCI/LBCI group due to a worse PTA.
Conclusions Peripheral HL could be associated with the absence of significant β-amyloid deposition in patients with CI and characteristic of the pure-LBCI and non-ADCI/LBCI groups.

참고문헌 (Reference)

1 Gibb WR, "The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease" 51 : 745-752, 1988

2 Attems J, "The overlap between vascular disease and Alzheimer’s disease--lessons from pathology" 12 : 206-, 2014

3 McKeith I, "Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies : a phase III, multicentre study" 6 : 305-313, 2007

4 Gurgel RK, "Relationship of hearing loss and dementia : a prospective, population-based study" 35 : 775-781, 2014

5 Uhlmann RF, "Relationship of hearing impairment to dementia and cognitive dysfunction in older adults" 261 : 1916-1919, 1989

6 Rahimi J, "Prevalence of mixed pathologies in the aging brain" 6 : 82-, 2014

7 Harrison Bush AL, "Peripheral hearing and cognition : evidence from the staying keen in later life(SKILL)study" 36 : 395-407, 2015

8 Yoo HS, "Olfactory dysfunction in Alzheimer’s disease-and Lewy body-related cognitive impairment" 14 : 1243-1252, 2018

9 Trumpp NM, "Losing the sound of concepts : damage to auditory association cortex impairs the processing of sound-related concepts" 49 : 474-486, 2013

10 Ye BS, "Longitudinal outcomes of amyloid positive versus negative amnestic mild cognitive impairments : a three-year longitudinal study" 8 : 5557-, 2018

11 Akil O, "Localization of synucleins in the mammalian cochlea" 9 : 452-463, 2008

12 Heidebrink JL, "Is dementia with Lewy bodies the second most common cause of dementia?" 15 : 182-187, 2002

13 Gomperts SN, "Imaging amyloid deposition in Lewy body diseases" 71 : 903-910, 2008

14 Lin FR, "Hearing loss and incident dementia" 68 : 214-220, 2011

15 Lin FR, "Hearing loss and cognitive decline in older adults" 173 : 293-299, 2013

16 Bucks RS, "Hearing loss and cognition in the Busselton Baby Boomer cohort : an epidemiological study" 126 : 2367-2375, 2016

17 Vitale C, "Hearing impairment in Parkinson’s disease : expanding the nonmotor phenotype" 27 : 1530-1535, 2012

18 Gennis V, "Hearing and cognition in the elderly. New findings and a review of the literature" 151 : 2259-2264, 1991

19 Blanc F, "Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease" 8 : 31-, 2016

20 Kang SW, "Effects of Lewy body disease and Alzheimer disease on brain atrophy and cognitive dysfunction" 92 : e2015-, 2019

21 Ye BS, "Distinguishing between dementia with Lewy bodies and Alzheimer’s disease using metabolic patterns" 87 : 11-17, 2020

22 Lennox G, "Diffuse Lewy body disease : correlative neuropathology using anti-ubiquitin immunocytochemistry" 52 : 1236-1247, 1989

23 Livingston G, "Dementia prevention, intervention, and care" 390 : 2673-2734, 2017

24 Li Y, "Comorbidity between and risk factors for severe hearing and memory impairment in older Americans" 43 : 416-421, 2006

25 McKhann G, "Clinical diagnosis of Alzheimer’s disease : report of the NINCDSADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer’s disease" 34 : 939-944, 1984

26 Perry EK, "Cholinergic and dopaminergic activities in senile dementia of Lewy body type" 4 : 87-95, 1990

27 Schneider JA, "Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology" 62 : 1148-1155, 2004

28 Griffiths TD, "Central auditory pathologies" 63 : 107-120, 2002

29 Gomperts SN, "Brain amyloid and cognition in Lewy body diseases" 27 : 965-973, 2012

30 Gallacher J, "Auditory threshold, phonologic demand, and incident dementia" 79 : 1583-1590, 2012

31 Loughrey DG, "Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia : a systematic review and meta-analysis" 144 : 115-126, 2018

32 Jellinger KA, "Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?" 16 : 34-, 2018

33 Pisani V, "An investigation of hearing impairment in de-novo Parkinson’s disease patients : a preliminary study" 21 : 987-991, 2015

34 Lee YG, "Amyloid-βrelated and unrelated cortical thinning in dementia with Lewy bodies" 72 : 32-39, 2018

35 Petrou M, "Amyloid deposition in Parkinson’s disease and cognitive impairment : a systematic review" 30 : 928-935, 2015

36 Ye BS, "Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients" 11 : 494-503, 2015

37 Uchida Y, "Age-related hearing loss and cognitive decline-the potential mechanisms linking the two" 46 : 1-9, 2019

38 Leverenz JB, "Advisory council July 2015 Meeting Presentation: Lewy Body dementias" U.S. Department of Health and Human Services