신생아 및 영아 혈중 Lipoprotein(a)치의 연령별 변동과 영향을 미치는 인자들에 대한 연구 = A Study Evloution of Lipoprotein(a), and the Factors that Effect on Lipoprotein(a) in Newborns

다국어 초록 (Multilingual Abstract)

Lipoprotein(a) ［Lp(a)］ is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease.
The aim of this study is to assess serum Lp(a) levels in 102 healthy newborns and to observe their evolution between 3 months, 6 months and 1 year by using ELISA method. Lp(a) is also compared with feeding formula methods and birth weight.
The results obtained were as follows :
1) The level of serum Lp(a) concentrations at birth was increases significantly after 3 months to 1 year of serum Lp(a) concentrations.
2) The level of serum Lp(a) concentrationas has no significant correlations between sex and feeding formulas.
3) Teh Lp(a) value of LGA infants was higher than low birth weight infants and normal birth weight infants, but it was within normal limit.
4) There were no significant correlations between maternal serum Lp(a) concentrations and Lp(a) concentrations in her infants.
In conclusion, our data suggest that the adequate timing for the screening test of Lp(a) in newborns is around 3 months after birth and we could not any statistically significant influence of the nutritional factors on the plasma Lp(a) concentrations at any age.