The Change of Tumor Interstitial Fluid Pressure Affected by Radiation Therapy in Patients with Uterine Cervix Cancer

다국어 초록 (Multilingual Abstract)

Purpose: To determine if the tumor interstitial fluid pressure (TIFP) and/or its change in patients with uterine cervix cancer can predict radiation therapy outcome.
Materials and Methods: In 24 biopsy proven uterine cervix cancer patients approachable by direct inspection and palpation, and with sufficient thickness (>0.8 cm) to permit accurate needle placement, we measured TIFP in near the center of tumor region before and during radiation therapy using a modified wick-in-needle technique. Tumor size was measured with clinical and radiological finding.
Results: The mean TIFP before therapy was 28.6±14.4 mmHg. TIFP before therapy had no significant relationship with tumor size (p=0.99). During fractionated radiation therapy, TIFP significantly decreased as tumor size regressed (p=0.005). TIFP before radiation therapy was not different between complete response group and partial or less response group (p=0.69). Mean TIFP decreased 10 mmHg in complete response group and 7.8 mmHg in partial or less response group.
Conclusion: The mean TIFP was elevated with 28.6± 14.4 mmHg before radiation therapy and lowered to 19.7± 10.0 mmHg during fractionated radiation therapy. The relationship between TIFP changes and tumor response has not been established. It was not definitive that TIFP change could be prognostic indicator of radiation response in patients with uterine cervix cancer. (J Korean Cancer Assoc 2001;33:16 -20)