척삭종의 세침흡인 세포학적 소견 = Cytologic Findings of Chordoma in Fine Needle Aspiration Cytology

다국어 초록 (Multilingual Abstract)

It is important to recognize the pathognomonic cytologic findings of chordoma, because of overlapping cytologic features between chordoma, chondrshdosarcoma, myxofilbrillary ependymoma, and metastatic adenocarcinoma. We reviewed the cytomorphologic features of 5 cases of chordoma diagnosed by fine needle aspiration cytology at Korean Cancer Center Hospital from 1987 to 2003. Clinical and radiographic findings of each case were reviewed. Four males and one female (29-54 years) had tumors involving the sacrum. Pain was the presenting symptom in 4 cases. The three cases showed moderate to high cellularity. In all cases, typical physaliferous cells with or without cytoplasmic processes were noted. In two cases, the background was myxoid with single scattered cells. Cell clusters showing cord-like arrangement were occasionally seen. The single or clustered cells showed mild cellular pleomorphism with slightly increased nuclear/cytoplasmic ratio. Mitotic figures were not seen. In our review, the recognition of physaliferous cells is the most important feature to diagnose chordoma and to differentiate it from other lesions mimicking chordoma.

참고문헌 (Reference)

1 "chordoma. Cytomorphologic finding in 14 cases diagnosed by fine needle aspiration." 47 : 202-208, 2003

2 "Stead R. Chordoma.cytologic and immunocytochemical study of four cases. Diagn Cytopathol 1986" sia (sia): 55-61,

3 "Sim SI. Fine needle aspiration cytologic of presacral chordoma" 133-9,

4 "Schumann GB. Aspiration cytology and cytochemistry of coccygeal chordoma A case report and review of the literature. Acta Cytol 1983" 178-83,

5 "Report of a case. Korean J Pathol 1993" 256-62,

6 "Redaelli G. Decisive role of immunocytochemistry in aspiration cytology of chordoma of the clivus A case report with review of the literature. J Laryngol Otol 1994" 426-30,

7 "Lee SY. A case of sacrococcygeal chordoma diagnosed by fine needle aspiration biopsy cytology. Korean J Pathol 1988" 356-9,

8 "Kindblom LG. Fine-needle aspiration biopsy in the preoperative diagnosis of chordoma A study of 17 cases with application of electron microscopic" 22-8,

9 "Gowda BM. Aspiration biopsy cytology of primary bone lesions. Acta Cytol 1993" 83-9,

10 Elliott EC, "Fulks RM. Aspiration cytology of metastatic chordoma" 658-62,

11 "Fine needle aspiration of cervical chordoma: A case report." 8 : 93-97, 1997

12 "Fine needle aspiration cytology of intraoral lesions." 9 : 155-160, 1998

13 "Diagnostic histopathology of tumors." Churchill Livingstone 1584 -, 2000

14 "Diagnosis of clival chordoma by fine needle aspiration of an oropharyngeal mass : A case report." 39 : 507-510, 1995

15 "Cytologic features of the chordoma: Report of five cases." 12 : 105-110, 2001

16 "Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues." 28 : 264-271, 2003

17 "Cytologic diagnosis of a chordoma without physaliferous cells: A case report." 12 : 131-134, 2001

18 "Coelho LH. Chordoma of rhinopharynx Report of a case. Acta Cytol 1974" 425-8,

19 "Chordoma : A cytologic study with histologic and radiologic correlation." 93 : 40-51, 2001

20 "Callery RT. Cytologic diagnosis of a chordoma without physaliferous cells. Diagn Cytopathol 1988" 144-7,

21 "Anders KH. Fine needle aspiration cytology of primary bone lesions. Acta Cytol 1987" 177-84,