Aldose Reductase Inhibitory Activity of Scrophularia Species

다국어 초록 (Multilingual Abstract)

Effects of the species Scrophularia takesimensis, S. kakudensis, S. boreali-koreana, and S. buergeriana on rat lens aldose reductase inhibition have been investigated. Among them, the extracts of S. kakudensis and S. boreali-koreana were exhibited good inhibitory potencies compared with those of S. takesimensis and S. buergeriana. The IC50 values of the aerial part extracts from S. kakudensis and S. boreali-koreana were demonstrated 0.46 and 0.35 mg/ml, respectively.

참고문헌 (Reference)

1 이윤미, "한국산 한약재 (생약) 추출물의 알도즈 환원 효소 억제 효능 검색과 꽃개오동의 수정체 혼탁 억제 (I)" 한국생약학회 39 (39): 165-173, 2008

2 Beyer-Mears, A, "lomerular polyol accumulation in diabetes and its prevention by oral sorbinil" 33 : 604-607, 1984

3 Beyer-Mears, A, "Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor" 34 : 15-21, 1985

4 Matsumoto, T, "Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats" 107 : 231-237, 2008

5 Ziegler, D, "Polyneuropathy in the diabetic patient-updata on pathogenesis and management" 19 : 2170-2175, 2004

6 Adisakwattana, S, "Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats" 78 : 406-412, 2005

7 Hotta, N, "Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy" 29 : 1538-1544, 2006

8 Qian, J, "Iridoid-related aglycone and its glycosides from Scrophularia ningpoensis" 31 : 905-911, 1992

9 Sang Hoon Jung, "Inhibitory Effects of Naturally Occurring Flavonoids on Rat Lens Aldose Reductase" 한국생약학회 10 (10): 35-39, 2004

10 Sato, S, "Inhibition of aldehyde reductase by aldose reductase inhibitors" 40 : 1033-1042, 1990

11 Park, S.U, "Genetic transformation of the figwort, Scrophularia buergeriana Miq., an Oriental medicinal plant" 21 : 1194-1198, 2003

12 Van Heyningen, R, "Formation of polyol by the lens of the rat with sugar cataract" 184 : 194-196, 1959

13 Engerman, R.L, "Experimental galactosemia produces diabetic-like retinopathy" 33 : 97-100, 1984

14 Ahn, Y. H, "Ecological characteristics and distribution of native Scrophularia takesimensis in Ulleung Island" 14 : 1087-1092, 2005

15 Chung, B.S, "Dictionary of Korean folk medicine" Young Lim Sa 910-, 1990

16 Constantino, L, "Diabetes complications and their potential prevention: aldose reductase inhibition and other approaches" 19 : 3-23, 1999

17 Kawanishi, K, "Aldose reductase inhibitors from the nature" 10 : 1353-1374, 2003

18 Jesús Ángel, "Aldose reductase inhibitors from natural sources" 20 : 243-251, 2003

19 Chalk, C, "Aldose reductase inhibitors for the treatment of diabetic polyneuropathy" 4 : 2007

20 Drel, V.R, "Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis" 21 : 667-676, 2008

21 Collins, J.B, "Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rats lens" 16 : 242-243, 1977

22 Ward, J.D, "Advance in metabolic disorders (suppl. 2): The polyol pathway in the neuropathy of early diabetes" Academic press 425-, 1973

23 Sun, W, "A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathway" 55 : 2757-2762, 2006