Down-regulation of Transforming growth factor β-activated kinase 1 by Nordihydroguaiaretic Acid and corresponding anti-inflammatory effects in RAW264.7 macrophage cell line : RAW264.7 macrophage cell line에서 나타나는 Nordihydroguaiaretic Acid에 의한 Transforming growth factor β-activated kinase 1의 감소효과와 항염증효과

다국어 초록 (Multilingual Abstract)

Inflammation serves a protective function in controlling infections and promoting tissue repair. However, if the inflammatory reaction is mis-regulated or prolonged, it can also cause tissue damage and inflammation-related disease such as sepsis, rheumatoid arthritis, and possibly cancer.
Originally, transforming growth factor β-activated kinase 1 (TAK1) was reported as a kinase that is activated in response to TGF-β treatment. However the subsequent studies revealed that TAK1 is an important signaling molecule in mediating immune responses. TAK1 was reported as a regulator of mitogen-activated protein kinase family induced by immune responses as well as NF-_(K)B signaling pathway. Since NF-_(K)B is an important transcription factor that are activated by various inflammatory cytokines and LPS, TAK1 was regarded as a useful target for developing anti-inflammatory drug.
Nordihydroguaiaretic acid (NDGA), a well known lipoxygenase inhibitor, exerts many effects on various cellular events, including cell proliferation and cell differentiation. It has also been known that NDGA suppresses inflammatory response although the precise mechanism was not elucidated yet.

목차 (Table of Contents)

• I. Introduction = 1
• II. Materials and Methods = 4
• III. Results = 7
• IV. Discussion = 19
• V. References = 21