Poster Session : PS 0297 ; Geriatrics : The Relationship of Metformin and Frailty Syndrome in Elderly with Type 2 Diabetes Mellitus = Poster Session : PS 0297 ; Geriatrics : The Relationship of Metformin and Frailty Syndrome in Elderly with Type 2 Diabetes Mellitus

다국어 초록 (Multilingual Abstract)

Background: Type 2 diabetes (T2DM) was characterised with insulin resistance and defi ciency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was no data that showed the relationship of metformin therapy to frailty syndrome. Methods: This was a case control study conducted in subjects =60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the fi-40 item criteria. Statistical analysis was done with SPSS 20. 0, where chisquare method was used in bivariate and logistic regression method in multivariate analysis. Results: Frailty syndrome was found in 25% of subjects (n=59), with median age of 72 years old (SD 6. 27) and median of fi-40 item score was 0. 18 (SD 0. 085). Metformin was found to have a signifi cant relationship with frailty syndrome in the elderly diabetics, which retained signifi cant value after multivariate analysis (adjusted OR 0. 043; 95% CI 0. 019-0. 099; p<0. 001). Conclusions: Metformin was associated with independently lower risk of frailty syndrome in elderly diabetics.