Production of 5-hydroxyvalerate-containing Polyhydroxyalkonates by Metabolically Engineered Escherichia coli

다국어 초록 (Multilingual Abstract)

Practical use of biodegradable biopolymers has been an inevitable choice for the globe given the current environmental crisis including plastic pollution and climate change. Accordingly, it has become increasingly important to produce various polyhydroxyalkanoates (PHAs) since they are naturally occurring polyesters and exhibiting a variety of physical properties and thus material performances in accordance with the type of monomers employed and their compositions. To this end, a number of microorganisms including natural PHA-producer and nonnatural PHA-producer have been metabolically engineered for PHA production and among them, recombinant Escherichia coli has been the model microorganism capable of producing various PHAs. Thus, we devised 5-hydroxyvalerate (5HV)-containing PHAs production system in E. coli through a series of metabolic engineering strategies. Here, we will present the development of metabolically engineered E. coli strains for the production of PHAs consisting of 5HV as monomeric units.