Synthesis and Magnetic Characteristics of Gamma Phase Iron oxide and Magnesium Iron oxide Nanoplates for Magnetic Hyperthermia Therapy

다국어 초록 (Multilingual Abstract)

We report magnetic nanomaterials for magnetic hyperthermia therapy. We successfully synthesis gamma phase iron oxide nanoplates (gIONPLs) using thermal decomposition method and ‘O2 adding’ to helped oxidation of nanomaterials. Normally, synthesis method of iron oxide nanoparticles (IONPs) is 2 temperature steps for reaction and we followed same temperature steps. One of added method ‘O2 adding’ help oxidation of IONPs to formed gamma phase. AMF generator induced mild frequency and magnetic field (100 kHz and 140 Oe) for harmless to human body generally used range of hyperthermia therapy. Gamma phase IONPLs are usually formed spinel structure. Alkali and alkali earth metals can doped on spinel structure. Magnesium is one of the alkali earth metal that can doped on gIONPs. We used U87MG, FsaII and HFB cells to in vitro, hyperthermia test and observed greatly therapeutic effects. Our gIONPLs and Mg-gIONPLs have potential therapeutic effects on cancer in human body by high temperature magnetic hyperthermia therapy.