Ultrasonic flow-through filtration of microparticles in a microfluidic channel using frequency sweep technique

다국어 초록 (Multilingual Abstract)

Many studies have been conducted on the filtration of microparticles using the acoustic radiation force of ultrasonic standing wave. The present work concerns a flow-through particle filtration method by utilizing frequency varying ultrasound. The periodical frequency sweep of the ultrasonic standing wave translocates particles across a microchannel, where particles in fluid flow are filtrated without barriers. The present filtration technique in a microfluidic channel was proposed conceptually in the 199 0s. However, its experimental realization on actual particles in a microfluidic channel has not been carried out in a notable way. Several sizes of polystyrene microspheres (10 µm to 90 µm) and silicon carbide (SiC) particles (37 µm) suspended in water were applied as a test sample. For filtration of those particles, a Y-branched microfluidic channel with one inlet and two outlets was made out of steel and acrylic as a form of modulized device. Ultrasound of a few MHz in band frequency (1.75 MHz to 3.05 MHz) was transmitted into one side of the channel wall to generate a standing wave field in fluid flow. The periodical frequency sweep operation showed successful filtration performance, whereby particles in water flowed into one outlet and purified water flowed into the other outlet of the Y branch of the channel.

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