수영운동이 류마티스 관절염 모델 마우스의 혈청 염증지표 및 연골에서의 HIF-2α mRNA 발현에 미치는 영향 = Effects of Swimming Exercise on Serum Inflammatory Markers and HIF-2α mRNA Expression of Cartilage in Rheumatoid Arthritis Model Mice

다국어 초록 (Multilingual Abstract)

The purpose of the present study was to investigate the effects of swimming exercise on serum inflammatory markers and HIF-2α mRNA expression of cartilage in rheumatoid arthritis model mice. Experiment animal were randomly assigned to swimming exercise group (n=9) and control group (n=9). Collagen-induced arthritis (CIA) was induced in male DBA/1J mice by intradermal injection of bovine collagen-II in Freund’s incomplete adjuvant (IFA). The swimming exercise group trained for 30 min/day, for 4 day/week for 6 weeks. Six weeks swimming exercise significantly reduced serum inflammatory makers (IL-6, TNF-α) and HIF-2α mRNA expression in cartilage while increasing the concentration of IL-10. Also, arthritic scores significantly reduced. Swimming exercise improved inflammatory response markers in mice with rheumatoid arthritis, suggesting that it can be a useful physical strategy in mice with rheumatoid arthritis. Future research should focus on finding optimal type and dose of exercise.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 연구 방법
• 3. 결과 및 해석
• 4. 논의
• 5. 결론
• REFERENCES

참고문헌 (Reference)

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