<P>Nanoscale drug carriers play an important role in regulating the delivery, permeability, and retention of the drugs. Although various carriers have been used to encapsulate anticancer drugs, natural biomaterials are of great benefit for deliv...
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https://www.riss.kr/link?id=A107672990
2012
-
SCOPUS,SCIE
학술저널
8216-8223(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Nanoscale drug carriers play an important role in regulating the delivery, permeability, and retention of the drugs. Although various carriers have been used to encapsulate anticancer drugs, natural biomaterials are of great benefit for deliv...
<P>Nanoscale drug carriers play an important role in regulating the delivery, permeability, and retention of the drugs. Although various carriers have been used to encapsulate anticancer drugs, natural biomaterials are of great benefit for delivery and controlled release of drugs. We used the electrospray deposition system to synthesize gliadin and gliadin-gelatin composite nanoparticles for delivery and controlled release of an anticancer drug (e.g., cyclophosphamide). The size profile and synthesis of nanoparticles was characterized by dynamic light scattering and X-ray diffractometry. Cyclophosphamide was gradually released from the gliadin nanoparticles for 48 h. In contrast, the gliadin-gelatin composite nanoparticles released cyclophosphamide in a rapid manner. Furthermore, we demonstrated that breast cancer cells cultured with cyclophosphamide-loaded 7% gliadin nanoparticles for 24 h became apoptotic, confirmed by Western blotting analysis. Therefore, the gliadin-based nanoparticle could be a powerful tool for delivery and controlled release of anticancer drugs.</P><P><B>Graphic Abstract</B>
<IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2012/langd5.2012.28.issue-21/la300691n/production/images/medium/la-2012-00691n_0008.gif'></P>
바이오나노융합기술 인력 양성사업 (1415128317) / 2012 / 산업전문인력역량강화 / 주재범 / 한양대학교 산학협력단 / 지식경제부 / 154,000,000
바이오나노융합기술산업화인력양성사업단 (1345196951) / 2012 / 2단계연구중심대학육성(0.5) / 정일엽 / 한양대학교 / 교육과학기술부 / 301,984,020
바이오나노융합기술 인력 양성사업 (1415128317) / 2012 / 산업전문인력역량강화 / 주재범 / 한양대학교 산학협력단 / 지식경제부 / 154,000,000
바이오나노융합기술산업화인력양성사업단 (1345196951) / 2012 / 2단계연구중심대학육성(0.5) / 정일엽 / 한양대학교 / 교육과학기술부 / 301,984,020