Base‐promoted insertion reactions of alkynes into the C–C σ‐bonds of α‐cyano ketones were established to construct highly functionalized conjugated olefins or chromone derivatives via transition metal‐free tandem reactions. These reactions...
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https://www.riss.kr/link?id=O120373895
2017년
-
1615-4150
1615-4169
SCI;SCIE;SCOPUS
학술저널
3079-3084 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Base‐promoted insertion reactions of alkynes into the C–C σ‐bonds of α‐cyano ketones were established to construct highly functionalized conjugated olefins or chromone derivatives via transition metal‐free tandem reactions. These reactions...
Base‐promoted insertion reactions of alkynes into the C–C σ‐bonds of α‐cyano ketones were established to construct highly functionalized conjugated olefins or chromone derivatives via transition metal‐free tandem reactions. These reactions are initialized through the nucleophilic attack of α‐cyano ketones to alkynones followed by intramolecular nucleophilic addition/ring‐opening to furnish the cyano‐containing alkenes. In the cases of alkynones bearing an ortho‐halide‐substituted aryl ring, a further C–O bond coupling reaction occurs to afford chromone derivatives in good to high yields. Various alkynones bearing alkyl or aryl substituents were compatible in the reaction. This reaction has the potential to become a general synthetic protocol for the preparation of cyano‐substituted olefins and chromones due to the abundance of easily accessible starting materials possessing diverse substituent groups.
Carbonyl Ylides Derived from Palladium Carbenes: The Impressive Fluorine Effect