치아우식 저항성군과 감수성군의 Streptococcus mutans에 대한 혈청과 이하선 타액의 자연항체 수준 = Natural Antibody Levels to Streptococcus mutans in Caries-Resistant and -Susceptible Subjects

다국어 초록 (Multilingual Abstract)

The levels of serum and parotid salivary antibodies from dental caries resistant(CR) (DMFT=0) and caries-susceptible(CS) (DMFT≥10) subjects to Streptococcus mutans were determined. In addition, the ability of serum and saliva containing these antibodies to neutralize S. mutans virulence activities was tested.
S. mutans cells to be used as antigens were grown in either non-dialyzed or dialyzed Todd-Hewitt medium. The antibody titers were determined by enzyme-linked immunosorbant assay.
The level of serum IgG antibody to S. mutans whole cell antigen was significantly higher in CR individuals than in CS subjects. This difference in antibody levels between CR and CS groups was observed only when the whole cell antigen was prepared in dialyzed medium. No difference in salivary antibody levels was detected between the two groups. The sera and salivas were found not to be able to neutralize the virulence activities of this organism.
The present study suggests that anti-S. mutans IgG antibodies in human serum have a role in the control of dental caries.