梅毒의 僞陽性反應에 對한 硏究 = Study of Biological False Positive Reaction for Syphilis

다국어 초록 (Multilingual Abstract)

The serodiagnostic test for syphilis employed with the greatest frequency in this country is the VDRL procedure which is one of the flocculation test utilizing cardiolipin-lecithin assay antigen. As well known, the immunologically nonspecific nature of this test relegates it only to screening test, so that all the sera displaying reactive VDRL in the absence of definite evidence of present or past syphilis should be confirmed by using the specific treponemal antigen tests.
The Trponema pallidum hemagglutination assay(TPHA) which was first described by Rathlev in 1965 and established as more improved and standardized procedure in serodiagnosis of syphilis by Tomizawa and Kasamatus(1966) has been found to be as sensitive and specific as the technically more complicated Fluorescent treponemal antibody absorption (FTA-ABS) or Treponema pallidum immobilization (TPI) procedure by many investigators from different part of the world. The TPHA has also been found to have definite advantage over the other tests because it is easy to perform and economic.
Sera from 4801 presumed normal persons, 2472 pregnant women and 5911 patients with various diseases other than syphilis were screened with the standard VDRL procedure as described and recomended by Difco laboratories. Fourty-eight out of the presumed normal persons, 22 out of the pregnant women and 144 out of the patient group with various diseases other than syphilis showed reactive VDRL under 1:4 sera without definite evidence of syphilis and these 214 sera from 214 persons were the subject of the present study.
Twenty(41.7%) out of the 48 sera from presumed normal persons, 14(63.7%) out of the 22 sera from pregnant women and 96 (66.6%) out of the 144 patient group with various diseased other than syphilis showed reactive TPHA. One hundred and thirty of the total 214 sera which showed reactive VDRL were found to be TPHA reactive.
The results were as follows;
1. The biological false positive ratio for syphilis was 39.2% using comparison of VDRL test with TPHA. The BFP ratio was 58.3%, 36.3%, 33.3% in presumed normal persons, in pregnant women and in patient group with various diseases other than syphilis.
2. The overall incidence of syphilis was 3.47%, 2.42%, 3.7% in presumed normal persons, in pregnant women and in patient group with various diseases other than syphilis respectively. The average incidence was 3.38%.
3. The incidence of syphilis of spouse was 26.7%.

목차 (Table of Contents)

• 1. 서론
• 2. 연구대상 및 방법
• 3. 결과
• 4. 고찰
• 5. 결론
• 6. 참고문헌