Influenza A 바이러스가 가토의 상악동 점막에 미치는 병리조직학적 변화와 세균부착성에 관한 연구 = Histopathological Changes and Bacterial Aadherence to the Maxillary Sinus Mucosa of Rabbits after Inoculation of Influenza A virus

다국어 초록 (Multilingual Abstract)

There are considerable evidences that viral upper respiratory tract infection precedes the episodes of acute sinusitis. Yet the causal relationship between viral upper respiratory tract infection and sinusitis has not been established conclusively. It has been reported that damages of the ciliated epithelium and decreased mucociliary clearance play important roles in the development of acute sinusitis and influenza A virus also has been reported to augment the adherence of microorganism to host cells and induce polymorphonuclear leukocyte dysfunction.
The purpose of this study was to determine the direct effects of viral infection on the mucosal epithelium, i.e., the histopathologic changes and effect on the adherence of Streptococcus pneumoniae to the sinus mucosa during the experimental influenza A virus-induced infection.
Experimental maxillary sinusitis was induced in New Zealand white rabbits by inoculating influenza A virus : strain A/Korea/1/80(H3N2). Rabbits were examined histopathologically at different intervals up to 28 days after inoculation.
Ciliated cells appeared to be the primary target and maximum damage was observed at the 7th day observation. Other prominent histopathologic findings were acute inflammatory cell infiltration, capillary engorgement, subepithelial hemorrhage and tissue edema. Regeneration of cilia and ciliated cells started from 5 days after viral infection. Four weeks were required to restore the ciliated epithelium to normal.
The adherence of Streptococcus pneurnoniae on the sinus mucosa was significantly increased at 3rd(p<0.05) and 7th day (p<0.01) after inoculation compared with the control group.
These results suggest that influenza A virus infection may result in mucosal changes as well as increase the bacterial adherence, but it recover without significant sequelae.
Therefore, a careful observation for secondary bacterial infection would be necessary in early stage of viral infection.