Neo-Darwinian theory based on the premise that the genome is an "unstable" and "mutable" entity. In fact, there are several phenomena that seem to support the evolution via genetic variation. However, modern molecular biology has also revealed that th...
Neo-Darwinian theory based on the premise that the genome is an "unstable" and "mutable" entity. In fact, there are several phenomena that seem to support the evolution via genetic variation. However, modern molecular biology has also revealed that the genome is essentially "stable" to ensure the stability of genetic information from generation to generation. The DNA repair machinery is an example of irreducibly complex system made up of sophisticated protein network. In addition to DNA repair system, cell cycle arrest followed by apoptosis operates in the cell when DNA damage is detected. This machinery prohibits the accumulation of genetic instability in cells. If genetic instability is escaped from the above surveillance system, the life would be in danger because of tumor generation. Therefore, genomic stability could be a challenge to Neo-Darwinian theory.