한약재(산약과 반하)에 의한 직업성 알레르기 1 예 = Occupational Rhinitis and Asthma Caused by Herb Materials

다국어 초록 (Multilingual Abstract)

There has been no case report of occupational allergy induced by herb materials. We report a case of occupational asthma and rhinintis caused by herb materials, Sanyak (Radix Discorae) and Banha (Rhizoma pinelliae). He has worked to cut herb mateials for three years. He began to feel sneezing, rhinorrhea, coughing and chest tightness since one year ago. Allergy skin prick test revealed positive responses to cat fur (6×4/ 25×24), orchard grass (3×3/23×16), timothy grass (7×7/30×22), rye grass (4×3/25×20), ragweed (2×2/l4×14), Banha extract (2×2/30×25), Sanyak extract (3×3/32×28) and histamine (3×3/25×20), Banha extract (2×2/30×25), Sanyak extract (3×3/32×28) and histamine (3×3/26×$lt;mm$gt;). RAST revealed positive results to g₃(class 2) and e₁, (class 1). The broncho-provocation test showed dual asthmatic response with Sanyak, and early asthmatic response with Banha. Although the initial methacholine bronchial challenge test showed a negative result, airway hyperresponsive ness to methacholine developed at first day after Banha bronchoprovocation test and recovered to normal at seventh day. Specific IgE and IgG₄antibody to Sanyak extract were detected by enzyme linked immunosorbent assay and there was no binding of specific IgG and IgG₄antibody to Banha extract.
It is suggested that Sanyak can induce IgE-mediate bronchoconstriction in an exposed worker, and non- immunologic mechanism is suggested on Banha-induced bronchoconstriction.