Lignan Glycosides from the Twigs of <i>Chaenomeles sinensis</i> and Their Biological Activities

다국어 초록 (Multilingual Abstract)

<P>Phytochemical investigation of the twigs of <I>Chaenomeles sinensis</I> led to the isolation and identification of six new lignan glycosides, chaenomiside A–F (<B>1</B>–<B>6</B>), along with five known ones (<B>7</B>–<B>11</B>). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (<B>1</B>–<B>11</B>) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-activated murine microglial cells and the secretion of nerve growth factor (NGF) in a C6 rat glioma cell line. Compound <B>6</B> significantly reduced NO levels in the murine microglia BV2 cells with an IC<SUB>50</SUB> value of 21.3 μM, and compounds <B>1</B>, <B>3</B>, and <B>6</B> were potent stimulants of NGF release with stimulation levels of 151.74 ± 6.77%, 144.31 ± 7.49%, and 167.61 ± 18.5%, respectively.</P><P><B>Graphic Abstract</B>
<IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2015/jnprdf.2015.78.issue-5/acs.jnatprod.5b00090/production/images/medium/np-2015-00090g_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5b00090'>ACS Electronic Supporting Info</A></P>