Metronomic Chemotherapy with Toceranib Phosphate for Treatment of a Chemodectoma in a Dog

다국어 초록 (Multilingual Abstract)

A 10-year-old, spayed, female Cocker Spaniel was referred to our hospital with a history of a cough anddyspnea. The patient was tentatively diagnosed with a chemodectoma based on clinical features evident onechocardiography and computed tomography. Metronomic chemotherapy utilizing toceranib phosphate as well asmedications for congestive heart failure were administered. During the period chemotherapy was administered (ninemonths from the time of diagnosis), clinical improvement was noted without the development of any adverse effects.
However, clinical signs recurred after chemotherapy was discontinued at the owner’s request. When the patient wasreevaluated via computed tomography, it was found that the size of the mass had increased. The patient developedsevere dyspnea secondary to recurrent pleural effusion and was euthanized 65 days after clinical signs reappeared.
A necropsy was performed and the patient was definitively diagnosed with a chemodectoma based on histopathologicand immunohistochemical analysis. This case report describes the clinical application of metronomic chemotherapywith toceranib phosphate, which is a tyrosine kinase inhibitor, in the treatment of a chemodectoma. We propose thatthis treatment may improve the quality of life and result in a prolonged survival time compared to treatment withmedications for congestive heart failure alone.

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