Nano-Fabrication and Characterization of CMOS Integrable Enzymeless Glucose Micro-Sensors : Nano-Fabrication and Characterization of CMOS Integrable Enzymeless Glucose Micro-Sensors

다국어 초록 (Multilingual Abstract)

Diabetes is a disease in which the pancreatic hormone insulin is no longer produced in sufficient quantity or activity to control sugar metabolism. It is essential for some diabetics to monitor and control glucose levels hourly or daily. Typically, most of the diabetics suffer pain due to use of a hypodermic needle and excessive expanses, since most of commercialized glucose sensors are disposable, which they are just useful once. Since they are analyzed by using electrochemical analysis method and use enzymes, living creatures, they are limited to use in in-vivo and continuously monitoring glucose levels. Recently, non-disposable glucose sensors have been announced by using optical and microwave analysis methods. However, there are no commercial products available due to an extremely low sensitivity and a high cost.
To overcome these drawbacks, mesoporous platinum (Pt) film is investigated by using nano-fabrication technology for developing enzymeless and electrochemical analysis based glucose micro-sensors with high sensitivity and low cost. The mesoporous platinum (Pt) film is also combined with micro-pillar platinum electrode in order to increase output response current of the electrochemical glucose sensor by enlarging reactivated sensing area. These nano-pore arrayed platinum electrodes areutilized for fabricating the enzymeless glucose micro-sensors are fabricated on silicon substrate, which can be fully integrated with CMOS read-out circuitry. The fabricated enzymeless glucose micro-sensors are characterized and analyzed in various chemical solutions to check their usability in in-vivo and continuously monitoring systems.

목차 (Table of Contents)

• Chapter 1. Introduction = 13
• 1.1 Diabetes and glucose detection = 13
• 1.2 Glucose sensors = 14
• Chapter 2. Mesoporous Pt electrodes = 19
• 2. 1 Introduction = 19
• 2. 2 Experimental method = 20
• 2. 2. 1 Reagents and instrumentation = 20
• 2. 2. 2 Fabrication procedures = 21
• 2. 3 Results and discussions = 31
• 2. 3. 1 Comparison of mesoporous Pt and Pt black electrodes = 31
• 2. 3. 2 Comparison of mesoporous Pt and mesoporous Pt film on micro-pillar Pt electrodes = 38
• 2. 4 Summary = 46
• Chapter 3. Enzymeless glucose micro-sensor = 47
• 3. 1 Introduction = 47
• 3. 2 Experimental method = 48
• 3. 2. 1 Reagents and instrumentation = 48
• 3. 2. 2 Fabrication procedures = 49
• 3. 3 Results and discussions = 52
• 3. 4 Summary = 57
• Chapter 4. Conclusion = 58