Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes

다국어 초록 (Multilingual Abstract)

Background: The prevalence of type 2 diabetes in elderly people has increased dramatically in the last few decades. This study wasdesigned to clarify the clinical characteristics of type 2 diabetes in patients aged ≥80 years according to age of onset.
Methods: We reviewed the medical records of 289 patients aged ≥80 years with type 2 diabetes at the outpatient diabetes clinics ofKangwon National University Hospital from September 2010 to June 2014. We divided the patients into middle-age-onset diabetes(onset before 65 years of age) and elderly-onset diabetes (onset at 65+ years of age).
Results: There were 141 male and 148 female patients. The patients had a mean age of 83.2±2.9 years and the mean duration of diabeteswas 14.3±10.4 years. One hundred and ninety-nine patients had elderly-onset diabetes. The patients with elderly-onset diabeteshad a significantly lower frequency of diabetic retinopathy and nephropathy, lower serum creatinine levels, lower glycated hemoglobin(HbA1c) levels, and similar coronary revascularization and cerebral infarction rates compared to those with middle-age-onsetdiabetes. There was no frequency difference in coronary revascularization and cerebral infarction and HbA1c levels between threesubgroups (<5, 5 to 15, and ≥15 years) of diabetes duration in elderly onset diabetes. However, both in the elderly onset diabetesand middle-age-onset diabetes, the cumulative incidence of retinopathy was increasing rapidly according to the duration of diabetes.
Conclusion: We report that individuals with elderly-onset diabetes have a lower frequency of diabetic retinopathy and nephropathyand similar cardiovascular complications compared to those with middle-age-onset diabetes.

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