이종장기이식의 최신지견 = Current Status of Solid Organ Xenotransplantation

다국어 초록 (Multilingual Abstract)

Solid organ xenotransplantation using transgenic pig organs is proposed as an alternative method for allo-transplantation. To accomplish this, immunologic and non-immunologic barriers for xenotransplantation should be overcome, and experiments on pigs to non-human primates (NHP) are now ongoing for clinical application. Before the clinical experiment, public consensus about ethical decisions must be considered. The results of NHP experiments on solid organ xenotransplantation are improving, and it is expected that xeno-solid organs can be used as new organs for human patients in the future.

참고문헌 (Reference)

1 Gibson T, "Zoografting: a curious chapter in the history of plastic surgery" 8 : 234-242, 1995

2 Sautermeister J, "Xenotransplantationtheological- ethical considerations in an interdisciplinary symposium" 22 : 174-182, 2015

3 Roux FA, "Xenotransfusions, past and present" 14 : 208-216, 2007

4 Cooper DK, "Will the pig solve the transplantation backlog" 53 : 133-147, 2002

5 Kim K, "Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons" 19 : 256-264, 2012

6 Chen G, "The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy" 81 : 273-283, 2006

7 Cooper DKC, "The pathobiology of pig-to-primate xenotransplantation: a historical review" 23 : 83-105, 2016

8 Hara H, "The immunology of corneal xenotransplantation: a review of the literature" 17 : 338-349, 2010

9 Sanchez PG, "State of art: clinical ex vivo lung perfusion: rationale, current status, and future directions" 31 : 339-348, 2012

10 Ibrahim Z, "Selected physiologic compatibilities and incompatibilities between human and porcine organ systems" 13 : 488-499, 2006

11 Reemtsma K, "Renal heterotransplantation in man" 160 : 384-410, 1964

12 Cooper DK, "Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature" 21 : 397-419, 2014

13 Phelps CJ, "Production of alpha 1,3-galactosyltransferase- deficienct pigs" 299 : 411-414, 2003

14 Padler-Karavani V, "Poenial impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk" 18 : 1-5, 2011

15 Iwase H, "Pig-to-baboon heterotopic heart transplantation: exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens" 22 : 211-220, 2015

16 Iwase H, "Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date" 22 : 302-309, 2015

17 Soin B, "Physiological aspects of pig-to-primate renal xenotransplantation" 60 : 1592-1597, 2001

18 Springer SA, "Parallel evolution of a self-signal: humans and new would monkeys independently lost the cell surface sugar Neu5Gc" 66 : 671-674, 2014

19 Kim H, "Outcomes of alpha 1,3-GT-knockout porcine heart transplants into a preclinical nonhuman primate model" 45 : 3085-3091, 2013

20 황성수, "No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation" 한국실험동물학회 30 (30): 90-93, 2014

21 Yamada K, "Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha 1,3-galactosyltransferase gene-knockout donors and the cotransplanplantation of vascularized thymic tissue" 11 : 32-34, 2005

22 Zhang MC, "Lamellar keratoplasty treatment of fungal corneal ulcers with acellular porcine corneal stroma" 15 : 1068-1075, 2015

23 Lexer G, "Hyperacute rejection in an discordant (pig to baboon) cardiac xenograft model" 5 : 411-418, 1986

24 Deschamps JY, "History of xenotransplantation" 12 : 91-109, 2005

25 Hardy JD, "Heart transplantation in man. Developmental studies and report of a case" 188 : 1132-1140, 1964

26 Mohiuddin MM, "Genentically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation" 148 : 1106-1113, 2014

27 Najarian JS, "Experimental xenotransplantation: a personal history" 10 : 10-15, 2003

28 Choi HJ, "Efficacy of pig-to-rhesus lamellar corneal xenotransplantation" 52 : 6643-6650, 2011

29 Cooper DK, "Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon" 7 : 238-246, 1988

30 Lambrigts D, "Discordant organ xenotransplantation in primates: world experience and current status" 66 : 547-561, 1998

31 Kubicki N, "Current status of pig lung xenotransplantation" 23 (23): 247-254, 2015

32 Ekser B, "Current status of pig liver xenotransplantation" 23 (23): 240-246, 2015

33 Iwase H, "Current status of pig kidney xenotransplantation" 23 (23): 229-233, 2015

34 Cowan PJ, "Controlling coagulation dysregulation in xenotransplantation" 16 : 214-221, 2011

35 Taniguchi S, "Clinical xenotransplantation: past, present and future" 79 : 13-19, 1997

36 Cooper DK, "Clinical lung xenotransplantation: what donor genetic modifications may be necessary" 19 : 144-158, 2012

37 Choi HJ, "Blockade of CD40-CD154 costimulatory pathway promotes long-term survival of full-thickness porcine corneal grafts in nonhuman primates: clinically applicable xenocorneal transplantation" 15 : 628-641, 2015

38 Lee RS, "Blockade of CD28-B7, but not CD40-CD154, prevents costimulation of allogeneic porcine and xenogeneic human anti-porcine T cell responses" 164 : 3434-3444, 2000

39 Starzl TE, "Baboon-to-human liver transplantation" 341 : 65-71, 1993

40 Bailey LL, "Baboon-to-human cardiac xenotransplantation in a neonate" 254 : 3321-3329, 1985

41 Cooper DK, "A brief history of clinical xenotransplantation" 23 (23): 205-210, 2015