Homology Modeling of Cysteinyl Leukotriene1 Receptor

목차 (Table of Contents)

• Abstract
• 1. Introduction
• 2. Material and Methods
• 2.1. Template Selection
• 2.2. Homology and Threading based Modeling of CysLT1
• 2.3. Validation of CysLT1
• 3. Results and Discussion
• 3.1. Template Selection
• 3.2. Model Generation
• 3.3. Model Validation
• 4. Conclusions
• References

참고문헌 (Reference)

1 C. Colovos, "Verification of protein structures : patterns of non-bonded atomic interactions" 2 : 1511-1519, 1993

2 Y. Ogawa, "The role of leukotrienes in airway inflammation" 118 : 789-798, 2006

3 H. M. Berman, "The protein data bank" 28 : 235-242, 2000

4 X. Dong, "Structure-based drug design using GPCR homology modeling : Toward the discovery of novel selective CysLT2 antagonists" 62 : 754-763, 2013

5 S. C. Lovell, "Structure validation by Cα geometry : φ, ψ and Cβ deviation" 50 : 437-450, 2003

6 P. Montuschi, "Pharmacological modulation of leukotriene pathway in allergic airway disease" 12 : 404-412, 2007

7 V. Capra, "Molecular and functional aspects of human cysteinyl leukotriene receptors" 50 : 1-11, 2004

8 J. C. Mobarec, "Modern homology modeling of G-protein coupled receptors : which structural template to use?" 52 : 5207-5216, 2009

9 H. M. Sarau, "Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor" 56 : 657-663, 1999

10 Y. Zhang, "I-TASSER server for protein 3D structure prediction" 9 : 1-8, 2008

11 A. Maekawa, "GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4" 106 : 11685-11690, 2009

12 C. Parravicini, "GPR17 : Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors" 9 : 263-, 2008

13 G. Woszczek, "Functional characterization of human cysteinyl leukotriene 1 receptor gene structure" 175 : 5152-5159, 2005

14 M. Bäck, "Functional characteristics of cysteinylleukotriene receptor subtypes" 71 : 611-622, 2002

15 C. Corrigan, "Expression of the cysteinyl leukotriene receptors cysLT1 and cysLT2in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis" 115 : 316-322, 2005

16 B. K. Kuntal, "Easy-Modeller : A graphical interface to MODELLER" 3 : 226-, 2010

17 Y. Kanaoka, "Cysteinyl leukotrienes and their receptors : cellular distribution and function in immune and inflammatory responses" 173 : 1503-1510, 2004

18 J. Theron, "Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function" 1-16, 2014

19 Y. Hui, "Cysteinyl leukotriene receptor" 64 : 1549-1557, 2002

20 N. Eswar, "Comparative protein structure modeling with MODELLER" 5 : 1-5, 2006

21 J. D. Thompson, "CLUSTAL W : improving the sensitivity of progressive sequence weighting, position-specific gap penalties and weight matrix choice" 22 : 4673-4680, 1994

22 S. F. Altschul, "Basic local alignment search tool" 215 : 403-410, 1990