F-45 Changes of exhaled volatile organic compounds during recovery from acute exacerbation of chronic obstructive pulmonary disease = F-45 Changes of exhaled volatile organic compounds during recovery from acute exacerbation of chronic obstructive pulmonary disease

다국어 초록 (Multilingual Abstract)

Background and objectives: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a well known risk factor for increased mortality and decline in lung function. Spirometry has limitation in reflecting airway inflammation during recov-ery phase of the acute exacerbation of COPD. We aimed to find biomarkers of exhaled volatile organic compounds (VOCs) of the patients suffering from acute exacerbation of COPD. Methods: A Prospective panel study was performed from May 2016 to September 2016 in Seoul National University Bundang Hospital (SNUBH) respiratory clinic.We enrolled patients with COPD having acute exacerbations. Breath samples were col-lected at baseline, 1 week and 4 weeks later. Breath was collected into Tenax tubes with Bio-VOCTM breath sampler and ambient air was also collected each time to eliminate the influence of external contamination. The exhaled VOCs of samples were assayed by gas chromatography - mass spectrometry (GC-MS). Analyses were conducted by linear mixed-effects model. Results: Five patients participated in the study; all of them were male and ex-smokers. Mean age was 73.4 and their mean percent predicted FEV1 was (67.6±10.6)%. Four of VOCs; allyl methyl sulfide, dimethyl sulfide, 2-methylfuran, methyl propyl sulfide were raised and three of VOCs; E-1-methylsulfanyl-1-propene, 3-methylthiophene, 1-propanol fell significantly dur-ing recovery from exacerbation of COPD. Conclusions: Our study showed that seven VOCs may qualify as candidate biomarkers for detecting and monitoring ex-acerbation of COPD.