증례 / Phenobarbital에 의한 anticonvulsant hypersensitivity syndrome 1례 = A case of anticonvulsant hypersensitivity syndrome induced by phenobarbital

다국어 초록 (Multilingual Abstract)

Anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatai drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants such as phenytoin, carbamazepine, and phenobarbital. In most cases, AHS characterized by fever, rash, lymphadenopathy and multiorgan-system abnormalities. Fatal outcomes are most often associated with liver failure. We experienced a 35-years-old man presenting typical characteristics of phenobarbital induced AHS. He presented fever, rash, lymphadenopathy, hepatitis, lung involvement and hematologic abnormalities. After use of systemic steroid, symptoms, signs and laboratory abnormalities were gradually disappeared. We report a case of AHS diagnosed by characteristic clinical and laboratory findings with a brief review of the literature.