Anti - HBc 단독양성인 만성간질환 환자에서 중합효소 연쇄반응을 이용한 혈청 HBV DNA 의 검출 , anti - HBe 및 anti - HBc 역가 = HBV DNA , Anti - HBe Titers and Anti - HBe in Patients with Chronic Liver Diseases and Isolated Serum Anti - HBc

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Objectives: The interpretation of isolated anti-HBc is very complex. One of the possibility is the role of a surrogate marker for low level HBV carriers, particularly in high titers of anti-HBc. Methods : Hepatitis B virus (HBV) DNA was tested in 43 objects that have antibody against hepatitis B core antigen (anti-HBc) as the isolated serological marker of HBV infection by the polymerase chain reaction (PCR). Anti-HBc titers were presented by Cut off point Counter Per Minute/Patient Count Per Minute (C/P ratios). HBV marks were tested by Abbott kits by radioimmunoassay. Results : HBV DNA was detected in 9 of 43 (20.9%) patients with liver disease. C/P ratios in 43 patients were higher (12.9±8.1) than that of normal control (4.6±0.7, p<0.005) but no difference was found between HRV DNA positive and negative group. Anti-HBe was positive in 4 of 9 HBV DNA positive objects. Conclusions : HBV DNA amplification by the PCR is the best method for the diagnosis of low level HBV carriers among isolated anti-HBc positive objects, Anti-HRc titers can not be the only way that detect low level HBV carriers any more. Anti-HBe should be checked in objects with isolated anti-HBc who are under the suspicion of low level HBV carriers. More cautions sould be payed on evaluation and management of isolated anti-HBc positive blood for the diagnosis and prevention of HBV infection by medical personell, expecially in blood bank.