<P>Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum ...
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https://www.riss.kr/link?id=A107659351
Kim, J.H. ; Jeun, E.J. ; Hong, C.P. ; Kim, S.H. ; Jang, M.S. ; Lee, E.J. ; Moon, S.J. ; Yun, C.H. ; Im, S.H. ; Jeong, S.G. ; Park, B.Y. ; Kim, K.T. ; Seoh, J.Y. ; Kim, Y.K. ; Oh, S.J. ; Ham, J.S. ; Yang, B.G. ; Jang, M.H.
2016
-
SCI,SCIE,SCOPUS
학술저널
507-5168(4662쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum ...
<P>Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies.</P>
Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells