Advances in the field of phosphorus chemistry are documented, by revealing the synthetic utility of previously underutilized quaternary phosphiranium salts (QPrS) as three‐chain‐atom electrophilic building blocks. Notably, control of their challen...
Advances in the field of phosphorus chemistry are documented, by revealing the synthetic utility of previously underutilized quaternary phosphiranium salts (QPrS) as three‐chain‐atom electrophilic building blocks. Notably, control of their challenging C‐centered electrophilicity is disclosed with an expedient synthesis of tertiary β‐anilino phosphines as a proof‐of‐concept.
C versus P selectivity: Quaternary phosphiranium salts (QPrS) are a fascinating yet underutilized class of phosphorus building blocks with instability and site‐electrophilicity issues. The challengingC‐centered nucleophilic ring opening of these salts, by reaction with aniline derivatives, is now reported and demonstrates the potential synthetic utility of QPrS.