A fraction from crude extract of Galega officinalis L. was purified by gel filtration on SephadexG-25, Sepharose 4B, and ion-exchange chromatography on diethylaminoethyl (DEAE) cellu-lose. The fraction with molecular weight 10 140 kDa apears to have a...
A fraction from crude extract of Galega officinalis L. was purified by gel filtration on SephadexG-25, Sepharose 4B, and ion-exchange chromatography on diethylaminoethyl (DEAE) cellu-lose. The fraction with molecular weight 10 140 kDa apears to have a polysaccharide na-ture, including protein. The fraction inhibits platelet aggregation initiated by 25 mM adeno-sine 59-diphosphate (ADP), 10 mg/ml collagen, and 0.8 U/ml thrombin with the 50% inhibitingconcentration (IC 50) being 1.2 mg/ml for ADP, and the IC 10 being 15.1 mg/ml for collagenand IC10 19.6 mg/ml for thrombin.29