The effects of circumstantial factors on β-amyloid peptide (β-AP) behavior, penetration, and aggregation were studied using cellular automata (CAs). To identify the mechanisms and relationships between the factors and the resulting behavior, β-AP w...
The effects of circumstantial factors on β-amyloid peptide (β-AP) behavior, penetration, and aggregation were studied using cellular automata (CAs). To identify the mechanisms and relationships between the factors and the resulting behavior, β-AP was simulated using over-critical, and under-critical conditions. In the case of the simulation using over-critical conditions, the a -AP penetrated and aggregated on the surface of the lipid membrane. However, when β-AP was simulated using under-critical conditions, it did not aggregate but only penetrated the surface of the lipid membrane. From the simulation results, circumstantial factors such as pH, oligomer concentration, and solubility were all found to have an important effect on β-AP behavior.