The role of Pin1 in the development and treatment of cancer

다국어 초록 (Multilingual Abstract)

Protein phosphorylation and post-phosphorylationevents regulate many cellular signaling pathways.
Peptidyl-prolyl isomerase (Pin1) is the only peptidyl-prolylcis/trans isomerase that interacts with numerous oncogenicor tumor suppressive phosphorylated proteins, causesconformational changes in target proteins, and eventuallyregulates the activities of such proteins. These alterationsin activity play a pivotal role in tumorigenesis. Since Pin1is overexpressed and/or activated in various types of cancers,and the dysregulation of proline-directed phosphorylationcontributes to tumorigenesis, Pin1 represents anattractive target for cancer therapy. This review willdescribe the role of Pin1 in cancer and the current status ofPin1 inhibitor development.

참고문헌 (Reference)

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