Suppression Effect of Curcuma longa Rhizome-Derived Components against Nitric Oxide Synthase

다국어 초록 (Multilingual Abstract)

The inhibitory effects of Curcuma longa rhizome-derived materials against nitric oxide (NO) pro-duction were assessed. The inhibitory effect (57%) on NO production was evidenced by the meth-anol extract of C. longa at 1 µg/mL. In the fractionation of the methanol extract, the ethyl acetate fraction evidenced an inhibitory effect greater than 62.1% at 1 µg/mL. The active constituent was identified as curcumin. Curcumin exerted potent inhibitory effects of 78.7 and 65.7% at concentra-tions of 1 and 0.5 µg/mL, respectively. Furthermore, the inhibitory effect of ar-turmerone was mea-sured as 31.3 and 15.8% at 1 and 0.5 µg/mL, respectively. The iNOS expression-suppressive effects of curcumin were assessed via western blot analysis. Our results suggest that curcumin and ar-tur-merone may prove useful in the development of new types of NO inhibitors.

참고문헌 (Reference)

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