저빈도 rTMS의 적용이 만성 뇌졸중환자의 인지기능에 미치는 영향

국문 초록 (Abstract)

본 연구는 저빈도 반복경두개자기자극(rTMS)이 만성 뇌졸중 환자의 인지기능에 미치는 영향을 알아보기 위해 실시 하였다. MMSE-K와 한국어판 BCRS-K를 통해서 선별된 만성 뇌졸중 환자 30명을 대상으로 3개의 군으로 무작위로 나누었 다. 실험군 Ⅰ(n=10)은 소리만 동일시간 적용하게 하였고, 실험군 Ⅱ(n=10)은 손상 측에 1 Hz rTMS를, 실험군 Ⅲ(n=10)은 손상반대측에 1 Hz rTMS를 적용하여 주 5회, 1일 20분, 2주간 중재하였다. 인지기능의 변화를 알아보기 위해서 중재 전, 1주 후, 2주 후, 3개월 후 시점에서 CERAD-K 점수를 측정하였다. 연구 결과 즉각 기억단어는 실험군 Ⅰ에 비교하여 실험군 Ⅱ와 실험군 Ⅲ에서 2주 후와 3개월 후에 통계학적으로 유의한 차이를 보였고(p<.05), 재인 기억단어에서는 실험군 Ⅲ에서 2주 후와 3개월 후에 통계학적으로 유의한 차이가 나타났다(p<.05). 지연 기억단어는 실험군 Ⅰ에 비해 실험군 Ⅲ에서 3개월 후에 통계학적으로 유의한 차이를 보였다(p<.05). 따라서 본 연구결과를 통해서 뇌졸중 환자에서 저빈도 rTMS의 적용이 인지재활에 긍정적인 영향을 줄 수 있을 것으로 생각된다.

다국어 초록 (Multilingual Abstract)

This study repeated low-frequency transcranial magnetic stimulation (rTMS) to evaluate the effects on cognitive function in chronic stroke patients. Among the chronic stroke patients, 30 patients selected by MMSE-K and BCRS-K were divided randomly into 3 groups. Group I (n=10) had only sound applied, group II (n=10) were applied 1 Hz rTMS on the damaged side and group Ⅲ (n=10) were applied to 1 Hz rTMS on the opposite side for total 2 weeks, 20 minutes per a day, five times per a week. To examine the change in cognitive function, CREAD-K scores were measured before, 1 week, 2 weeks, and then 3 months after the intervention. The CREAD-K scores were measured before and 1 week, 2 weeks and 3 months after the interventions. The immediate recall memory showed a significant difference after 2 weeks and 3 months in groups Ⅱ and Ⅲ (p<.05), The recognition memory showed a significant difference after 2 weeks and 3 months in group Ⅲ (p<.05). The delayed recall memory showed significant differences after 3 months in group Ⅲ than in group Ⅰ (p<.05). Therefore, the application of low-frequency rTMS has a positive influence on the cognitive rehabilitation of chronic stroke patients.

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