연골재생에서 혈소판 풍부 혈장의 역할 = Role of Platelet Rich Plasma in Cartilage Regeneration

다국어 초록 (Multilingual Abstract)

Platelets are known as a natural source of various growth factors which contribute to cell activation and tissue regeneration. These released growth factors induce chemotaxis, cell proliferation, differentiation, and angiogenesis, and play a role in wound healing and regenerative process. Platelet rich plasma (PRP) is a concentrate of platelets. Except of platelets, substances needed for regeneration like fibronecrin, vitronectin are included in PRP. Thus, clinical application of PRP could be a part of promising therapy methods due to combination effects of various factors in PRP. A possible role of platelets in cartilage regeneration has been reported. Researchers found convincing evidences for activation of chondrocyte proliferation and increase of proteoglycan production. Recently, microRNAs were discovered that function as an inducer for differentiation of mesenchymal stem cells (MSCs) into chondrocytes. In this study, anti-inflammatory and regeneration effects of PRP in cartilage disease will be discussed.