Fabrication of mesoporous silica-covered gold nanostars for chemophototherapy

다국어 초록 (Multilingual Abstract)

Gold nanomaterials have attracted great interest in the fight against cancer due to their surface features.
In this study, gold nanostar (GNS) cloaked with mesoporous silica (GNS@mSiO2) carriers were preparedfor controlled drug release. The GNS core presents a branched morphology with tip-to-tip diameter of80–120 nm and core of 40–60 nm. In this system, GNS not only served as photothermal agent but alsoas Raman signal enhancement matrix. After encapsulating doxorubicin (DOX) within the GNS@mSiO2carrier, hyaluronic acid (HA) was coated on the GNS@mSiO2 surface to seal the loaded-drug of channels.
The obtained DOX-GNS@mSiO2/HA displayed pH/enzyme-triggered drug release and photothermalchemotherapeutic effect.

참고문헌 (Reference)

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