2LO-19 In vivo compatibility of chitosan-hydroxyapatite composite patch depedning on degree of deacetylation of chitosan = 2LO-19 In vivo compatibility of chitosan-hydroxyapatite composite patch depedning on degree of deacetylation of chitosan

다국어 초록 (Multilingual Abstract)

Chitosan is one of promising polymers for applications in various fields. However, despite diverse research studies conducted on its biocompatibility, its uses are still limited. The main factor that can affect its physical, chemical and biological properties is the degree of deacetylation (DOD), which represents the proportion of deacetylated units in the polymer. In this article, the in vivo biocompatibility of chitosan-hydroxyapatite composite with different DOD values of chitosan was investigated. The chitosan with the higher DOD induced a higher incidence of inflammation in skin cells. This basic study on the relationship between the DOD and inflammation is valuable for the development of further chitosan-based researches.