Role of human papillomavirus in development of skin tags = Role of human papillomavirus in development of skin tags

다국어 초록 (Multilingual Abstract)

Background: Skin tag is a commonly encountered benign cutaneous tumor located frequently in the intertriginous area. To date, the etiology of skin tag has been poorly understood.
Objectives: This study is aimed to clarify the biological relevance of specific types of human papillomavirus in the pathogenesis of skin tags.
Methods: Lesional skin samples of skin tags and healthy controls as negative controls and lesional skin samples of patients with condyloma as positive controls were retrieved. By using multiplex real-time polymerase chain reaction amplication and melting curve analysis, presence of 20 high risk and 20 low risk human papillomavirus types were analyzed.
Results: On multiplex real-time polymerase chain reaction analysis, the presence of 20 high-risk human papillomavirus types or 20 low-risk human papillomavirus types was not observed in all specimens from patients with skin tags. Human papillomavirus 6 (n = 2), 11 (n = 2) and 54 (n = 1) types were detected in positive controls. Polymerase chain reactions for negative controls showed negative results among the tested human papillomavirus types.
Conclusion: Although the specific types of human papillomavirus might be associated with the causation of skin tags, our pilot study showed the lack of association between 20 high-risk and 20 low-risk human papillomavirus types and skin tags.