Genomic Relationship of Salmonella enterica Serovar Typhimurium DT104 Isolates from Korea and the United States

다국어 초록 (Multilingual Abstract)

Salmonella enterica serovar Typhimurium DT104 (Salmonella Typhimurium DT104 or DT104) has been emerging as a common pathogen for human in Korea since 1997. In order to compare the genomic relationship and to search for the dominant strains in Korea, we conducted pulsed-field gel electrophoresis (PFGE) and IS200 fingerprinting of 25 epidemiological unrelated isolates from human and animals from Korea and cattle from America. Two Salmonella Typhimurium DT104 isolates from human in Korea and all 8 isolates from American cattle had indistinguishable patterns from the PFGE and IS200 fingerprinting but multidrug-resistant Salmonella Typhimurium isolates, including DT104, from Korean animals had diverse genetic patterns. The data suggest that a dominant DT104 strain might have circulated between Korean and American cattle and that it had a high level of clonality.

참고문헌 (Reference)

1 "The spread and antibioticresistance of Salmonella enterica serotype typhimuriumDT104 in Hungary" 48 : 95-105, 2001

2 "Surveillanceof antibiotic resistance in Salmonella" 2 : 19-20, 1997

3 "Salmonellosis associatedwith S typhimurium DT104 in the USA" 140 : 1997

4 "Salmonellaenterica serotype Typhimurium DT104 isolated fromhumans, United States, 1985, 1990, and 1995" 8 : 387-391, 2002

5 "Salmonella typhimurium DT104: A virulent anddrug-resistant pathogen" 39 : 559-565, 1998

6 "Rapid pulsed-field gel electrophoresis protocolfor typing of Escherichia coli O157 H7 and other gram-neg-ative organisms in 1 day" 35 : 2977-80, 1997

7 "PulseNet: The molecular subtypingnetwork for foodborne bacterial disease surveillance,United States" 7 : 382-389, 2001

8 "Partialcharacterization of a genomic island associated with the mul-tidrug resistance region of Salmonella enterica TyphymuriumDT104" 189 : 285-291, 2000

9 "Origins and consequences of antimicrobial-resistant nonty-phoidal salmonella implications for the use of fluoroquinolo-nes in food animals" 6 : 77-83, 2000

10 "Multiresistnatclones of Salmonella enterica The importance of dissemina-tion" 140 : 135-141, 2002

11 "Molecular characterizationof an antibiotic resistance gene cluster of Salmonella typhimu-rium DT104" 43 : 846-849, 1999

12 "Increasingspectrum of resistance in multiresistant Salmonella typhimurium" 347 : 1053-1054, 1996

13 "Evolution-ary origin of a monophasic Salmonella serovar revealedby IS200 profiles and restriction fragment polymorphisms of thefljB gene" 34 : 1641-1645, 1996

14 "Emergenceof multidrug-resistant Salmonela enterica serotype Typhimu-rium phage-type DT104 among salmonellae causing enteritidisin Israel" 121 : 555-559, 1998

15 "Emergence of multidrug-resistant Salmonellaenterica serotype Typhimurium DT104 infections in the UnitedStates" 1333-1338,

16 "Detection of multidrug-resistant Salmonellaenterica serotype typhimurium DT104 based on a gene whichconfers cross-resistance to florfenicol and chloramphenicol" 37 : 1348-1351, 1999

17 "Detection of multidrug-resistant Salmonella typhimurium DT104by multiplex polymerase chain reaction" 182 : 35-360, 2000

18 "DNAfingerprinting of Salmonella enterica subsp enterica serovartyphimurium with emphasis on phage type DT104 based onvariable number of tandem repeat loci" 41 : 1469-79, 2003

19 "Completenucleotide sequence of a 43-kilobase genomic island associatedwith the multidrug resistance region of Salmonella entericaserovar Typhimurium DT104 and its identification in phagetype DT120 and serovar Agona" 183 : 5725-32, 2001

20 "Characterization of multidurg-resistant Salmonella entericaserovar Typhimurium isolated in Japan" 39 : 2700-2703, 2001

21 "Characterization of Variant Salmonella Genomic Island 1Multidrug Resistance Regions from Serovars TyphimuriumDT104 and Agona" 46 : 1714-22, 2002

22 "Characterization and chromosomalmapping of antimicrobial resistance genes in Salmonella enter-ica serotype Typhimurium" 66 : 4842-4848, 2000

23 "Characteristics of epidemic multidrug resistant Salmonellaenterica serovar Typhimurium DT104 strains first isolated inKorea" 34 : 1-8, 2002

24 "Antimicrobial resistancein Salmonella enterica serovars Enteritidis and Typhimuriumisolated from animals in Korea comparison of phenotypicand genotypic resistance characterization" 86 : 295-301, 2002

25 "An outbreak of multidrug-resistant Salmonela enterica subsp DT104L linked to driedanchovy in Singapore" 128 : 1-5, 2002

26 "A virulent strain of Salmonella enterica sero-var London isolated in infants with enteritis traced by activesurveillance and molecular epidemiological study" 18 : 325-330, 2003