<P>A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of <I>Streptomyces</I> sp. KCTC 11604BP <I>fkbO</I> deletion mutant with 3-cyclohexene-1-carboxylic acid. Th...
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https://www.riss.kr/link?id=A107676017
2013
-
학술저널
944-947(4쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of <I>Streptomyces</I> sp. KCTC 11604BP <I>fkbO</I> deletion mutant with 3-cyclohexene-1-carboxylic acid. Th...
<P>A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of <I>Streptomyces</I> sp. KCTC 11604BP <I>fkbO</I> deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.</P>
<P>Graphic Abstract</P><P>A FK506 analogue containing a non-natural starter unit, 32-dehydroxy-FK506, was obtained through mutational biosynthesis.
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