人蔘成分이 mouse 組謝 中의 中間 sterols에 미치는 影響 = The effect of Panax Ginseng on intermediary sterols in mouse tissues

국문 초록 (Abstract)

1. 人蔘添加群의 mice조직에서는 Lipogensis를 促進하며, 高用量에서는 Ester型의 存在가 높으며 cholesterol의 代謝가 促進된다고 보며, 皮부에서는 유리型의 sterol가 많고, 肝장에서는 SAS/TS比가 90%이상이다.
2. 牛脂添加群의 mice의 각조직의 總 sterol値에서는 큰 變動은 없으나 腎장에서는 總sterol가 60% 增加하였다. 肝장에서는 유리型과 ester型이 平衡을 이루고 있고, 皮부조직의 sterol에는 큰 영향이 없다.
3. 牛脂와 人蔘高用量添加群에서는 각 조직의 總 sterol가 大略 50% 減少되었다.
4. 解脂劑인 Linoleic acid 添加群의 mice의 각조직에서의 總 sterol은 減少되며, ester型은 腎장에서 높다. Linoleic acid는 lipotropic effect가 잘 나타나고 있다고 추정된다.
5. Linoleic acid와 人蔘高用量添加群은 mice의 각조직에서 總 sterol가 거이 同一한 比率로 減少되므로 高脂肝, 高脂血症에 活用할 수 있다고 본다.

다국어 초록 (Multilingual Abstract)

1. Ginseng was revealed to activate the lipogensis in the mouse tissues. High dose of ginseng increased the levels of ester type sterol in the liver and the kidney, whereas free type sterol increased in the skin.
2. Tallow fat did not change the level of total sterol in every tissue, except that the level in the kidney increased to 60 per cent. The level of ester type sterol were equivalent to that of free type sterol in the liver. There is no sign of effect on the quantitative change of sterol in the skin.
3. The mixure of tallow fat and high dose of ginseng was revealed to decrease the level of total sterol to half in every tissue.
4. Linoleic acid, which is a lipolytic, reduced the total sterol level in every tissue, but the level of ester type sterol was higher in the kidney than in other tissues. The ratios of fast-acting sterol to slow-acting sterol per total sterols seem to be affected by linoleic acid through lipolytic action.
5. It was suggested that the linoleic acid can high dose of ginseng may be applicable for the treatment of hyperlipemia and fatty liver, since total sterol level in every tissue was reduced evenly by the feeding of those mixure.