Sodium Salicylate 投與家兎의 腹膜灌流에 關한 實驗的硏究 = Intermittent Peritoneal Dialysis of Sodium Salicylate in Rabbit.

다국어 초록 (Multilingual Abstract)

The expeximental peritoneal dialysis of sodium salicylate in rabbit was not described and an effective dialysate in its procedure was also not evaluated.
The intermittent peritoneal dialysis were performed in 21 rabbits with intravenous administration of sodium salicylate in this study. The electrolyte solution and amino acids solution were used as dialysates and those efficiencies were compared.
The electrolyte solution is a modified Grollman's solution with glucose in 1.5% and "Panamin" with glucose in 2% is used as the amino acids solution.
The electrolyte solution was used as diaIysare in 12 rabbits(group I experiment) and the aminoacid solution in 9 rabbits(group I1 experiment). In group 1 experiment, one hour dialysis was performed twice in 3 rabbits and three times in 9 rabbits.
In group II experiment, one hour dialysis was performed twice in all rabbits except one in which a 4 hour dialysis was done.
The concentration of sodium salicylate in dialysate and blood were measured twice or three times serially at an interval of one hour. The total plasma protein, serum sodium, potassium and calcium were measured before and after each dialysis.
In group I experiment, the blood sodium salicylate levels were markedly reduced after each dialysis in all cases.
The changes of the blood sodium salicylate levels in average during dialysis were 52.8mg%(45∼64mg%) in predialysis, 36.4mg% (26∼54.0mg%) in first hour dialysis, 30.8mg% (19.5∼40.1mg%) in second hour dialysis, and 24.7mg%(17.0∼38.0mg%) in third hour dialysis
The total amount of sodium salicylate dialysed into the dialyzate was 41.1mg%(39∼45.9mg%) in rabbits of 2 hours dialysis and was 46.0mg(29.6∼61.0mg) in rabbits of 3 hours dialysis. The dialized total amount of sodium salicylate corresponded t o 6.2% and 7.3% of the administered amount of sodium salicylate.
In group Ⅱ experiment, the blood sodium salicylate levels were markedly reduced in all cases except one in which four hour dia1ysis;was done. The changes of the blood sodium salicylate levels in average into the dialyzate was 44.7mg%(26.5-57,2mg%).
The dialized total amount of sodium salicylate corresponded to 7.35% of the administered amount of sodium salicylate respectively.
The results of these experiments showed that sodium salicylate was dialysed successfully in rabbits by the intermittent peritoneal dialysis and the dialysing effect of amino acid solution was superior to that of modified Grollman's electrolyte solution.

목차 (Table of Contents)

• Ⅰ. 緖論
• Ⅱ. 實驗方法 및 材料
• 1. 灌流方法
• 2. 化學分析
• Ⅲ. 實驗成績
• Ⅳ. 考察
• Ⅴ. 結論
• 參考文獻