RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Purpose: The use of anticonvulsants can cause side effects such as reduction of bone mineral density, requiring attention in growing children. The aim of our study is to investigate the effects of different anticonvulsants on bone mineral density in epileptic patients treated with monotherapy.
Methods: We retrospectively reviewed medical records of 60 subjects who visited the Pediatric Epilepsy Clinic of Bucheon St. Mary’s Hospital from January 2013 to December 2017. Bone mineral density was measured with dual photon absorptiometry every 6 months.
Results: The number of patients treated with oxcarbazepine, valproate and levetiracetam was 31, 16 and 13, respectively. Reduction of bone mineral density was seen in 8 out of 31 patients (25.8%, P=0.10) treated with oxcarbazepine, 9 out of 16 patients treated with valproate (56.3%, P=0.04) and 4 out of 13 patients treated with levetiracetam (30.8%, P=0.50).
Conclusion: There was a significant reduction of bone mineral density in patients treated with valproate compared to the other anticonvulsants in our study. We believe attention to bone mineral density is required in children treated with anticonvulsants.

번역하기

국문 초록 (Abstract)

목적: 항경련제 사용은 골밀도 감소와 같은 부작용을 일으킬 수 있고 지속적으로 성장하는 소아에서 주의가 필요하다. 단일 요법으로치료하는 뇌전증 환자에서 항경련제가 골밀도에 미치는 영향의 차이를 알아보고자 하였다.
방법: 2013년 1월부터 2017년 12월까지 부천성모병원에서 뇌전증치료를 하는 소아 환자 60명에 대해 후향적으로 살펴 보았다. Dual photo absorptiometry로 골밀도를 6개월마다 측정하였다.
결과: 전체 60명 중 Oxcarbazepine, Valproate, Levetiracetam으로 치료한 환자는 각각 31, 16, 13명이었다. Oxcarbazepine 치료 환자 31명 중 8명(25.8%, P =0.10), Valproate 치료 환자 16명 중 9명(56.3%, P =0.04), Levetiracetam 치료 환자 13명 중 4명(30.8%, P=0.50)에서 골밀도 감소가 관찰되었다.
결론: Valproate 투여 환자들에서 다른 항경련제 치료 환자보다 골밀도가 유의하게 감소되었다. 항경련제 치료를 하는 소아 뇌전증 환자의 골밀도에 대한 관심이 필요할 것으로 생각된다.

번역하기

목적: 항경련제 사용은 골밀도 감소와 같은 부작용을 일으킬 수 있고 지속적으로 성장하는 소아에서 주의가 필요하다. 단일 요법으로치료하는 뇌전증 환자에서 항경련제가 골밀도에 미치는...

참고문헌 (Reference)

1 Stoffel-Wagner B, "Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication" 39 : 1164-1173, 1998

2 Rättyä J, "Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy" 56 : 31-36, 2001

3 Morrell MJ, "Reproductive dysfunction in women with epilepsy:antiepileptic drug effects on sex-steroid hormones" 6 : 771-772, 2001

4 Binkovitz LA, "Pediatric dual-energy X-ray absorptiometry: technique, interpretation, and clinical applications" 37 : 303-313, 2007

5 Erbayat Altay E, "Evaluation of bone mineral metabolism in children receiving carbamazepine and valproic acid" 13 : 933-939, 2000

6 Trevathan E., "Epilepsy-associated bone mineral density loss should be prevented" 70 : 166-167, 2008

7 Jacoby A, "Epilepsy and social identity: the stigma of a chronic neurological disorder" 4 : 171-178, 2005

8 Chung S, "Effects of anti-epileptic drug therapy on bone mineral density in ambulatory epileptic children" 16 : 382-385, 1994

9 Gordon CM, "Dual energy X-ray absorptiometry interpretation and reporting in children and adolescents: the 2007 ISCD Pediatric Official Positions" 11 : 43-58, 2008

10 Tekgul H, "Bone mineral status in pediatric outpatients on antiepileptic drug monotherapy" 21 : 411-414, 2006