Co-precipitation of loperamide hydrochloride and polyethylene glycol using aerosol solvent extraction system

다국어 초록 (Multilingual Abstract)

The co-precipitation of loperamide hydrochloride (LPM) and polyethylene glycol (PEG) using aerosol solvent extraction system (ASES) was examined. Scanning electron microscopy - energy dispersive X-ray spectroscopy (SEM-EDS) analysis showed that the co-precipitation was achieved in various LPM-PEG mass ratios with changes in its morphology. In 10-50% PEG mass ratios, angular-shaped particles were formed, whereas in 65-90% PEG mass ratios, irregular-shaped particles were formed. X-ray diffraction (XRD) analysis of the co-precipitates revealed that the LPM retained amorphous structure, while, on the other hand, the PEG retained crystalline structure. Fourier transform infrared (FT-IR) spectra indicated carbonyl function group of LPM and ether function group of PEG appeared in the co-precipitates. Results of a dissolution test showed that the co-precipitates of LPM-PEG had higher dissolution rate compared to that of the raw material and processed LPM with ASES. Taken together, the co-precipitation of LPMPEG was achieved using ASES and higher in its dissolution rate.
EDS of 50% PEG precipitate showed that chlorine map (indicate LPM) and oxygen map (indicate PEG) are co-precipitated

참고문헌 (Reference)

1 J. Kluge, 48 : 176-, 2009

2 D. Q. M. Craig, 231 : 131-, 2002

3 M. P. Patil, 59 : 57-, 2009

4 A. T. M. Serajuddin, 88 : 1058-, 1999

5 H. Liu, 33 : 959-, 2007

6 I. Pasqualli, 364 : 176-, 2008

7 Y.-S. Youn, 59 : 117-, 2011

8 J. Chu, 369 : 85-, 2009

9 C. Leuner, 50 : 47-, 2000

10 C. P. Buckley, 254 : 695-, 1976

11 C.-W. Lee, 55 : 348-, 2010

12 M. Türk, 39 : 435-, 2007

13 J. Jung, 20 : 179-, 2001

14 E. Badens, 377 : 25-, 2009

15 A. Martin, 41 : 138-, 2007

16 O. I. Corrigan, 245 : 75-, 2002

17 S. Sethia, 272 : 1-, 2004

18 G. Muhrer, 308 : 69-, 2006

19 E. Reverchon, 97 : 1626-, 2007

20 E. Reverchon, 4 : 185-, 2008

21 E. Reverchon, 43 : 126-, 2007

22 D. J. Dixon, 39 : 127-, 1993

23 T.W. Randolph, 9 : 429-, 1993

24 B. Warwick, 41 : 1993-, 2002

25 M. E. Matteuci, 112 : 16675-, 2008

26 M. E. Matteuci, 25 : 2477-, 2008

27 M. E. Matteucci, 4 : 182-, 2007

28 E. Reverchon, 106 : 23-, 1999

29 A. Tenorio, 40 : 308-, 2008

30 M. A. Tavares Cordoso, 46 : 71-, 2008

31 H. Konno, 95 : 2692-, 2006

32 S. Kubota, 38 : 890-, 2009

33 M.-S. Kang, 183 : 15-, 2006

34 D.Q. M. Craig, 74 : 33-, 1991

35 Junho Chu, "Recrystallization of tetracycline hydrochloride using supercritical anti-solvent process" 한국화학공학회 26 (26): 1119-1124, 2009

36 "Loperamide hydrochloride tablets, USP32-NF27"