FCP 3 : Platelet rich plasma induced hair growth in alopecia patients partially through dermal papilla cell proliferation, BCl-2 and KGF up-regulation = FCP 3 : Platelet rich plasma induced hair growth in alopecia patients partially through dermal papilla cell proliferation, BCl-2 and KGF up-regulation

다국어 초록 (Multilingual Abstract)

Alopecia is a common disorder with significant negative impact on their social and psychological well-being. There are many modalities to treat various alopecia, such as oral finasteride, topical minoxidil, triamcinolone intralesional injection, excimer laser and so on. However, the treatment results of these treatment are not always satisfactory. In vitro study, PRP treated dermal papilla cells showed the increased cell proliferation rates, BCl-2 and KGF up-regulation. We tried to evaluate efficacy and safety of sequential treatment, Platelet-rich plasma(PRP) injection, followed by mesotherapy in various alopecia. Included in this study were males and females between the ages of 20 and 60 years, in good health. Two independent investigators evaluated clinical improvement using a quartile grading scale by comparing digital photographs taken prior to treatment and at 3 months after the last treatment. The result was a relatively clinical improvement in hair count and hair thickness demonstrated in all the patients. There were no significant side effects except mild pain, transient bleeding at injection or microneedling site. Taken together, PRP induced hair growth in alopecia patients partially through dermal papilla cell proliferation, BCl-2 and KGF up-regulation.