Secondary Appendiceal Tumors: A Review of 139 Cases

다국어 초록 (Multilingual Abstract)

Background/Aims: This study evaluated the clinicopathologic characteristics of patients with secondary appendiceal tumors (SATs). Methods: We performed a single-center, retrospective study of patients with pathologically confirmed SATs. Results: Among 180cases of appendiceal malignancies diagnosed between 2000 and 2007, 139 cases (77.2%, 46 male) were SATs. The median age at SAT diagnosis was 55years. The most common primary origin was the ovary. The mode of appendiceal involvement was metastasis in 122 and invasion in 17 patients. Extraappendiceal involvement was present in 134 patients.
The only manifestation that could be attributed to the SAT itself was appendicitis (n=8). Serosal involvement was predominant. The median survival after diagnosis of SAT was 22.6 months. In the Cox regression analysis,chemotherapy included in the treatment was the only factor associated with prolonged survival (hazards ratio, 0.12; 95% confidence interval, 0.06-0.23; p ＜0.001). Complete resection of the SAT had no influence on survival. Conclusions: SATs accounted for 77.2% of all pathologically diagnosed appendiceal malignancies. The most common origin was the ovary.
SATs were usually associated with widespread disease,and the median survival after SAT diagnosis was 22.6 months. Complete resection of the SAT had no influence on survival.

참고문헌 (Reference)

1 Bair MJ, "Urologic manifestations of acute appendicitis secondary to metastatic cervical cancer" 106 : 784-787, 2007

2 Schmutzer KJ, "Tumors of the appendix" 18 : 324-331, 1975

3 Klöppel G, "The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification" 1014 : 13-27, 2004

4 Blair NP, "Review of the pathologic diagnoses of 2,216 appendectomy specimens" 165 : 618-620, 1993

5 Reddy S, "Pancreatic resection of isolated metastases from nonpancreatic primary cancers" 15 : 3199-3206, 2008

6 Carr NJ, "Miscellaneous tumours of the appendix. In Pathology and genetics tumors of the digestive system" IARC Press 102-, 2000

7 Zelikowski A, "Metastatic carcinoma of the appendix:report of a case" 15 : 305-307, 1972

8 Rose PG, "Isolated appendiceal metastasis in early ovarian carcinoma" 64 : 246-247, 1997

9 Marsden DE, "Current management of epithelial ovarian carcinoma: a review" 19 : 11-19, 2000

10 Fong Y, "Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases" 230 : 309-318, 1999

11 Dieter RA Jr, "Carcinoma metastatic to the vermiform appendix:report of three cases" 13 : 336-340, 1970

12 Korea Ministry for Health, "Cancer facts and figures 2008" Korea Ministry for Health, Welfare and Family Affairs 2008

13 Pigolkin IuI, "Appendicular metastatic involvement in breast cancer" 70 : 46-48, 2008

14 Miller JS, "Appendiceal mass in a middle-aged woman. Endometrioid endometrial carcinoma metastatic to the appendix" 130 : 407-408, 2006

15 Gopez EV, "Acute appendicitis secondary to metastatic bronchogenic adenocarcinoma" 63 : 778-780, 1997