The effect of Periostracum Cicadae on capsaicin-induced model of atopic dermatitis in rats

국문 초록 (Abstract)

Objectives : 선태는 아토피 피부염에서 소양증 완화를 위해 사용되고 있다. 본 연구에서는 면역계 및 신경계 손상을 일으킨 rat model에서 선태 추출물이 소양증 완화에 효과가 있는지 알아보고자 한다.Methods : 출생 48시간 이내의 rat을 대상으로, capsaicin(50 mg/kg)을 피하 투여하였다. 임의로 선정된 12마리의 실험군에 3주 동안 선태 추출물(0.5g/kg)을 매일 경구 투여하였다. 이후 scratching behavior 와 dermatitis score를 측정하였다.Results : 선태 투여군과 대조군에서 scratching number 와 dermatitis score의 차이가 없었다.Conclusions : 위의 결과로부터 capsaicin으로 유발한 아토피 피부염 rat model에서 선태의 소양증 완화 효과가 없다는 것을 알 수 있었다. 아토피 피부염의 효과적인 치료를 위해 면역계 뿐만 아니라 신경계 손상 회복시키는 약물을 찾기 위한 더 많은 연구가 필요할 것으로 생각된다.

참고문헌 (Reference)

1 임영권, "한약의 아토피 피부염 치료에 대한 예비 임상 연구" 대한한방소아과학회 20 (20): 129-141, 2006

2 김지영, "선퇴의 항산화 및 항염 활성" 숙명여자대학교 대학원 2008

3 Yang L, "Two new N-acetyldopamine tetrapolymers from Periostracum Cicadae" 14 (14): 204-209, 2012

4 Al-Khafaji M, "Treatment by Chinese Herbal medicine Pompholyx eczema" 66 : 15-26, 2001

5 Michael JC, "The vanilloid receptor:A Molecular Gateway to the Pain Pathway" 24 : 487-517, 2001

6 Cheng HM, "The efficacy and safety of a Chinese herbal product (Xiao-Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial" 155 (155): 141-148, 2011

7 Michael JC, "TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation" 5 (5): 1107-1116, 2014

8 Jancso G, "Sensory neurotoxins:chemically induced selective destruction of primary sensory neurons" 210 (210): 83-89, 1981

9 Yosipovitch G, "Scratching and noxious heat stimuli inhibit itch in humans: a psychophysical study" 156 (156): 629-634, 2007

10 Metz M, "Pruritus:an overview of current concepts" 22 (22): 121-131, 2010

11 Jancso G, "Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones" 270 (270): 741-743, 1977

12 Stander S, "Pathophysiology of pruritus in atopic dermatitis: an overview" 11 (11): 12-24, 2002

13 Buddenkotte J, "Pathophysiology and therapy of pruritus in allergic and atopic diseases" 65 (65): 805-821, 2010

14 Donald L, "New insights into atopic dermatitis" 113 (113): 651-657, 2004

15 Takeda K, "Mouse models of allergic diseases" 21 (21): 660-665, 2009

16 Ständer S, "Itch in atopic dermatitis-pathophysiology and treatment" 18 (18): 289-296, 2010

17 Schmelz M, "Itch and pain" 34 (34): 171-176, 2010

18 Ma SP, "Immunologic inhibition and anti-allergic action of Cryptotympana atrata Fabricius" 14 (14): 490-493, 1989

19 The National College of Oriental Medicine Herbology Classroom, "Herbology" Youngrimsa 155-218, 1995

20 Kim DG, "Herb Medicinal Pharmacology" Shinilbooks 79-119, 2005

21 Jung DL, "Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats" 74 (74): 23-30, 2014

22 Back SK, "Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin;a potential rat model of human atopic dermatitis" 67 (67): 111-119, 2012

23 Holzer P, "Capsaicin : cellular targets, mechanisms of action, and selectivity for thin sensory neurons" 43 (43): 143-201, 1991

24 Kim MY, "Anti-inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenze in mice" 10 (10): 377-382, 2014

25 Jin H, "Animal models of atopic dermatitis" 129 (129): 31-40, 2009

26 Park JE, "Analgesic and Antiinflammatory Activities of Some Oriental Herbal Medicines" 32 (32): 257-268, 2001

27 Chang YT, "Alternative Therapy for Autosensitization Dermatitis" 32 (32): 668-673, 2009